Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for developing sporadic
Alzheimer's disease. How the interaction of APOE4 microglia with neurons differs from …

… Lorenzo Bozzelli et al. This is an open access article distributed under the Creative Commons
Attribution … P. Lorenzo Bozzelli and Seham Alaiyed contributed equally to this work. …

Recent increases in human longevity have been accompanied by a rise in the incidence of
dementia, highlighting the need to preserve cognitive function in an aging population. A …

DNA double-strand breaks (DSBs) are linked to neurodegeneration and senescence. However,
it is not clear how DSB-bearing neurons influence neuroinflammation associated with …

Memory disruption in mild cognitive impairment (MCI) and Alzheimer9s disease (AD) is poorly
understood, particularly at early stages preceding neurodegeneration. In mouse models …

Drugs that target monoaminergic transmission represent a first‐line treatment for major
depression. Though a full understanding of the mechanisms that underlie antidepressant efficacy …

Hippocampal sharp wave ripples (SWRs) represent irregularly occurring synchronous
neuronal population events that are observed during phases of rest and slow wave sleep. SWR …

Disruptions to daily living, inflammation, and astrogliosis are characteristics of Alzheimer's
disease. Thus, circadian rhythms, nest construction, IL-1β and TNF-α, and glial fibrillary acidic …

The HIV‐1 protein Tat is continually released by HIV‐infected cells despite effective
combination antiretroviral therapies (cART). Tat promotes neurotoxicity through enhanced …

A major pathological hallmark of neurodegenerative diseases, including Alzheimer's, is a
significant reduction in the white matter connecting the two cerebral hemispheres, as well as in …