[HTML][HTML] Depression as a glial-based synaptic dysfunction

…, N Gonçalves, CA Gomes, PM Canas… - Frontiers in cellular …, 2016 - frontiersin.org
Recent studies combining pharmacological, behavioral, electrophysiological and molecular
approaches indicate that depression results from maladaptive neuroplastic processes …

Purinergic signaling orchestrating neuron-glia communication

…, L Dias, AP Simões, RA Cunha, PM Canas - Pharmacological …, 2020 - Elsevier
This review discusses the evidence supporting a role for ATP signaling (operated by P 2 X
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) in …

Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by β-amyloid peptides via p38 mitogen-activated protein kinase pathway

PM Canas, LO Porciúncula, GMA Cunha… - Journal of …, 2009 - Soc Neuroscience
Alzheimer's disease (AD) is characterized by memory impairment, neurochemically by
accumulation of β-amyloid peptide (namely Aβ 1-42 ) and morphologically by an initial loss of …

Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress

…, ÂR Tomé, P Agostinho, PM Canas… - Proceedings of the …, 2015 - National Acad Sciences
The consumption of caffeine (an adenosine receptor antagonist) correlates inversely with
depression and memory deterioration, and adenosine A 2A receptor (A 2A R) antagonists …

Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat

N Rebola, PM Canas, CR Oliveira, RA Cunha - Neuroscience, 2005 - Elsevier
Adenosine A 2A receptors are most abundant in the striatum where they control the
striatopallidal pathway thus controlling locomotion. Extra-striatal A 2A receptors are considerably …

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

N Rebola, AP Simões, PM Canas… - Journal of …, 2011 - Wiley Online Library
J. Neurochem. (2011) 117, 100–111. Abstract The blockade of adenosine A 2A receptors (A2AR)
affords a robust neuroprotection in different noxious brain conditions. However, the …

Enhanced role of adenosine A2A receptors in the modulation of LTP in the rat hippocampus upon ageing

AR Costenla, MJ Diógenes, PM Canas… - European Journal of …, 2011 - Wiley Online Library
Adenosine neuromodulation depends on a balanced activation of inhibitory A 1 (A 1 R) and
facilitatory A 2A receptors (A 2A R). Both A 1 R and A 2A R modulate hippocampal …

Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms

…, QY Huang, YJ Day, N Rebola, PM Canas… - Annals of …, 2008 - Wiley Online Library
Objective To investigate whether the motor and neuroprotective effects of adenosine A 2A
receptor (A 2A R) antagonists are mediated by distinct cell types in the 1‐methyl‐4‐phenyl‐1,2,…

A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain …

…, JE Coelho, N Ohtsuka, PM Canas… - Journal of …, 2008 - Soc Neuroscience
The function of striatal adenosine A 2A receptors (A 2A Rs) is well recognized because of
their high expression levels and the documented antagonistic interaction between A 2A Rs …

[HTML][HTML] Adenosine A2A receptors as biomarkers of brain diseases

A Moreira-de-Sá, VS Lourenço, PM Canas… - Frontiers in …, 2021 - frontiersin.org
Extracellular adenosine is produced with increased metabolic activity or stress, acting as a
paracrine signal of cellular effort. Adenosine receptors are most abundant in the brain, where …