[HTML][HTML] High-fat diet exacerbates cognitive decline in mouse models of Alzheimer's disease and mixed dementia in a sex-dependent manner

OJ Gannon, LS Robison, AE Salinero… - Journal of …, 2022 - Springer
Background Approximately 70% of Alzheimer’s disease (AD) patients have co-morbid vascular
contributions to cognitive impairment and dementia (VCID); this highly prevalent overlap …

Contributions of sex to cerebrovascular function and pathology

LS Robison, OJ Gannon, AE Salinero, KL Zuloaga - Brain research, 2019 - Elsevier
Sex differences exist in how cerebral blood vessels function under both physiological and
pathological conditions, contributing to observed sex differences in risk and outcomes of …

Histone deacetylase 8 regulates cortactin deacetylation and contraction in smooth muscle tissues

…, RA Cleary, R Wang, OJ Gannon… - … of Physiology-Cell …, 2014 - journals.physiology.org
Histone deacetylases (HDACs) are a family of enzymes that mediate nucleosomal histone
deacetylation and gene expression. Some members of the HDAC family have also been …

[HTML][HTML] Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer's disease

LS Robison, OJ Gannon, MA Thomas… - Journal of …, 2020 - Springer
Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer’s
disease (AD), likely contributing to disturbances in feeding behavior and metabolic function that …

[HTML][HTML] Menopause causes metabolic and cognitive impairments in a chronic cerebral hypoperfusion model of vascular contributions to cognitive impairment and …

OJ Gannon, JS Naik, D Riccio, FM Mansour… - Biology of sex …, 2023 - Springer
Background The vast majority of women with dementia are post-menopausal. Despite
clinical relevance, menopause is underrepresented in rodent models of dementia. Before …

High-fat diet-induced obesity causes sex-specific deficits in adult hippocampal neurogenesis in mice

…, AE Salinero, DA Riccio, C Abi-Ghanem, OJ Gannon… - Eneuro, 2020 - eneuro.org
Adult hippocampal neurogenesis (AHN) is suppressed by high-fat (HF) diet and metabolic
disease, including obesity and type 2 diabetes. Deficits in AHN may contribute to cognitive …

[HTML][HTML] Polo-like kinase 1 regulates vimentin phosphorylation at Ser-56 and contraction in smooth muscle

J Li, R Wang, OJ Gannon, AC Rezey, S Jiang… - Journal of Biological …, 2016 - ASBMB
Polo-like kinase 1 (Plk1) is a serine/threonine-protein kinase that has been implicated in
mitosis, cytokinesis, and smooth muscle cell proliferation. The role of Plk1 in smooth muscle …

[HTML][HTML] Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer's disease

LS Robison, OJ Gannon, AE Salinero… - Biology of Sex …, 2023 - Springer
Background Alzheimer’s disease (AD) is notably associated with cognitive decline resulting
from impaired function of hippocampal and cortical areas; however, several other domains …

[HTML][HTML] Sex-specific effects of high fat diet on cognitive impairment in a mouse model of VCID

AE Salinero, LS Robison, OJ Gannon… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
Mid-life metabolic disease (ie obesity, diabetes, prediabetes) causes vascular dysfunction
and is a risk factor for vascular contributions to cognitive impairment and dementia (VCID), …

[HTML][HTML] Recruitment of β-catenin to N-cadherin is necessary for smooth muscle contraction

T Wang, R Wang, RA Cleary, OJ Gannon… - Journal of Biological …, 2015 - ASBMB
β-Catenin is a key component that connects transmembrane cadherin with the actin
cytoskeleton at the cell-cell interface. However, the role of the β-catenin/cadherin interaction in …