[HTML][HTML] High-fat diet exacerbates cognitive decline in mouse models of Alzheimer's disease and mixed dementia in a sex-dependent manner
OJ Gannon, LS Robison, AE Salinero… - Journal of …, 2022 - Springer
Background Approximately 70% of Alzheimer’s disease (AD) patients have co-morbid vascular
contributions to cognitive impairment and dementia (VCID); this highly prevalent overlap …
contributions to cognitive impairment and dementia (VCID); this highly prevalent overlap …
Contributions of sex to cerebrovascular function and pathology
Sex differences exist in how cerebral blood vessels function under both physiological and
pathological conditions, contributing to observed sex differences in risk and outcomes of …
pathological conditions, contributing to observed sex differences in risk and outcomes of …
Histone deacetylase 8 regulates cortactin deacetylation and contraction in smooth muscle tissues
…, RA Cleary, R Wang, OJ Gannon… - … of Physiology-Cell …, 2014 - journals.physiology.org
Histone deacetylases (HDACs) are a family of enzymes that mediate nucleosomal histone
deacetylation and gene expression. Some members of the HDAC family have also been …
deacetylation and gene expression. Some members of the HDAC family have also been …
[HTML][HTML] Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer's disease
LS Robison, OJ Gannon, MA Thomas… - Journal of …, 2020 - Springer
Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer’s
disease (AD), likely contributing to disturbances in feeding behavior and metabolic function that …
disease (AD), likely contributing to disturbances in feeding behavior and metabolic function that …
[HTML][HTML] Menopause causes metabolic and cognitive impairments in a chronic cerebral hypoperfusion model of vascular contributions to cognitive impairment and …
OJ Gannon, JS Naik, D Riccio, FM Mansour… - Biology of sex …, 2023 - Springer
Background The vast majority of women with dementia are post-menopausal. Despite
clinical relevance, menopause is underrepresented in rodent models of dementia. Before …
clinical relevance, menopause is underrepresented in rodent models of dementia. Before …
High-fat diet-induced obesity causes sex-specific deficits in adult hippocampal neurogenesis in mice
…, AE Salinero, DA Riccio, C Abi-Ghanem, OJ Gannon… - Eneuro, 2020 - eneuro.org
Adult hippocampal neurogenesis (AHN) is suppressed by high-fat (HF) diet and metabolic
disease, including obesity and type 2 diabetes. Deficits in AHN may contribute to cognitive …
disease, including obesity and type 2 diabetes. Deficits in AHN may contribute to cognitive …
[HTML][HTML] Polo-like kinase 1 regulates vimentin phosphorylation at Ser-56 and contraction in smooth muscle
J Li, R Wang, OJ Gannon, AC Rezey, S Jiang… - Journal of Biological …, 2016 - ASBMB
Polo-like kinase 1 (Plk1) is a serine/threonine-protein kinase that has been implicated in
mitosis, cytokinesis, and smooth muscle cell proliferation. The role of Plk1 in smooth muscle …
mitosis, cytokinesis, and smooth muscle cell proliferation. The role of Plk1 in smooth muscle …
[HTML][HTML] Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer's disease
LS Robison, OJ Gannon, AE Salinero… - Biology of Sex …, 2023 - Springer
Background Alzheimer’s disease (AD) is notably associated with cognitive decline resulting
from impaired function of hippocampal and cortical areas; however, several other domains …
from impaired function of hippocampal and cortical areas; however, several other domains …
[HTML][HTML] Sex-specific effects of high fat diet on cognitive impairment in a mouse model of VCID
AE Salinero, LS Robison, OJ Gannon… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
Mid-life metabolic disease (ie obesity, diabetes, prediabetes) causes vascular dysfunction
and is a risk factor for vascular contributions to cognitive impairment and dementia (VCID), …
and is a risk factor for vascular contributions to cognitive impairment and dementia (VCID), …
[HTML][HTML] Recruitment of β-catenin to N-cadherin is necessary for smooth muscle contraction
T Wang, R Wang, RA Cleary, OJ Gannon… - Journal of Biological …, 2015 - ASBMB
β-Catenin is a key component that connects transmembrane cadherin with the actin
cytoskeleton at the cell-cell interface. However, the role of the β-catenin/cadherin interaction in …
cytoskeleton at the cell-cell interface. However, the role of the β-catenin/cadherin interaction in …