Functional properties of the neural cell adhesion molecule (NCAM) are strongly influenced
by polysialylation. We used gene-targeting to generate mice lacking ST8SiaIV/PST-1, one of …

Although the extracellular matrix plays an important role in regulating use-dependent
synaptic plasticity, the underlying molecular mechanisms are poorly understood. Here we …

Persistent anxiety after a psychological trauma is a hallmark of many anxiety disorders.
However, the neural circuits mediating the extinction of traumatic fear memories remain …

Polysialic acid (PSA) is a post-translational protein modification that is widely expressed
among neural cell types during development. Found predominantly on the neural cell adhesion …

Adaptive behaviour necessitates the formation of memories for fearful events, but also that
these memories can be extinguished. Effective extinction prevents excessive and persistent …

The speed of impulse transmission is critical for optimal neural circuit function, but it is unclear
how the appropriate conduction velocity is established in individual axons. The velocity of …

The extracellular matrix glycoprotein tenascin-C (TN-C) has been suggested to play important
functional roles during neural development, axonal regeneration, and synaptic plasticity. …

NCAM, a neural cell adhesion molecule of the immunoglobulin superfamily, is involved in
neuronal migration and differentiation, axon outgrowth and fasciculation, and synaptic plasticity…

Preclinical and clinical studies implicate endocannabinoids (eCBs) in fear extinction, but the
underlying neural circuit basis of these actions is unclear. Here, we employed in vivo …

The balance between excitation and inhibition controls fundamental aspects of the hippocampal
function. Here, we report an increase in the ratio of inhibitory to excitatory neurons in the …