Mitochondrial function in the brain links anxiety with social subordination

F Hollis, MA van der Kooij, O Zanoletti… - Proceedings of the …, 2015 - National Acad Sciences
Dominance hierarchies are integral aspects of social groups, yet whether personality traits
may predispose individuals to a particular rank remains unclear. Here we show that trait …

[HTML][HTML] Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations

…, M Fantin, E Rejmak, J Grosse, O Zanoletti… - Nature …, 2014 - nature.com
Chronic stress is a risk factor for the development of psychopathologies characterized by
cognitive dysfunction and deregulated social behaviours. Emerging evidence suggests a role …

[HTML][HTML] Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of dopamine D1 receptors

…, L Lozano, I Zalachoras, S Abad, O Zanoletti… - Molecular …, 2018 - nature.com
Benzodiazepines can ameliorate social disturbances and increase social competition,
particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying …

[HTML][HTML] Mitofusin-2 in the nucleus accumbens regulates anxiety and depression-like behaviors through mitochondrial and neuronal actions

E Gebara, O Zanoletti, S Ghosal, J Grosse… - Biological …, 2021 - Elsevier
Background Emerging evidence points to a central role of mitochondria in psychiatric disorders.
However, little is known about the molecular players that regulate mitochondria in neural …

[HTML][HTML] Impaired hippocampal neuroligin-2 function by chronic stress or synthetic peptide treatment is linked to social deficits and increased aggression

…, I Kraev, I Korshunova, J Grosse, O Zanoletti… - …, 2014 - nature.com
Neuroligins (NLGNs) are cell adhesion molecules that are important for proper synaptic
formation and functioning, and are critical regulators of the balance between neural excitation/…

eNAMPT actions through nucleus accumbens NAD+/SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress

…, I Guillot de Suduiraut, J Grosse, O Zanoletti… - Science …, 2022 - science.org
… (2 μM) to obtain the level of residual O 2 consumption (ROX) due to oxidative side reactions
outside of mitochondrial respiration. The O 2 flux obtained in each step of the protocol was …

[HTML][HTML] Hippocampal neuroligin-2 overexpression leads to reduced aggression and inhibited novelty reactivity in rats

C Kohl, O Riccio, J Grosse, O Zanoletti, C Fournier… - PloS one, 2013 - journals.plos.org
Disturbances of the excitation/inhibition (E/I) balance in the brain were recently suggested as
potential factors underlying disorders like autism and schizophrenia resulting in associated …

Opposite effects of stress on effortful motivation in high and low anxiety are mediated by CRHR1 in the VTA

…, S Astori, M Meijer, J Grosse, O Zanoletti… - Science …, 2022 - science.org
Individuals frequently differ in their behavioral and cognitive responses to stress. However,
whether motivation is differently affected by acute stress in different individuals remains to be …

Stress-induced depressive-like behavior in male rats is associated with microglial activation and inflammation dysregulation in the hippocampus in adulthood

JP Brás, IG de Suduiraut, O Zanoletti, S Monari… - Brain, Behavior, and …, 2022 - Elsevier
Neuroinflammation is increasingly recognized as playing a critical role in depression. Early-life
stress exposure and constitutive differences in glucocorticoid responsiveness to stressors …

Peripubertal stress-induced heightened aggression: modulation of the glucocorticoid receptor in the central amygdala and normalization by mifepristone treatment

…, S Tzanoulinou, O Riccio, O Zanoletti… - …, 2019 - nature.com
Despite the enormous negative impact of excessive aggression for individuals and societies,
there is a paucity of treatments. Here, using a peripubertal stress model of heightened …