We developed stable isotope labeling and mass spectrometry approaches to measure the
kinetics of multiple isoforms and fragments of tau in the human central nervous system (CNS) …

Adult-onset neurodegenerative diseases (AONDs) comprise a heterogeneous group of
neurological disorders characterized by a progressive, age-dependent decline in neuronal …

Ageing is the greatest risk factor for the development of Parkinson's disease. However, the
current dogma holds that cellular mechanisms that are associated with ageing of midbrain …

Formation of membrane-less organelles via liquid-liquid phase separation is one way cells
meet the biological requirement for spatiotemporal regulation of cellular components and …

Previous studies demonstrate that intrastriatal injections of fibrillar alpha-synuclein (α-syn)
into mice induce Parkinson's disease (PD)-like Lewy body (LB) pathology formed by …

Neurofibrillary tangles, composed of insoluble aggregates of the microtubule-associated
protein Tau, are a pathological hallmark of Alzheimer disease (AD) and other tauopathies. …

Aggregated filamentous forms of hyperphosphorylated tau (a microtubule-associated protein)
represent pathological hallmarks of Alzheimer's disease (AD) and other tauopathies. While …

Despite abundant epidemiological evidence in support of aging as the primary risk factor for
PD, biological correlates of a connection have been elusive. In this article, we address the …

Emerging studies suggest a role for tau in regulating the biology of RNA binding proteins (RBPs).
We now show that reducing the RBP T-cell intracellular antigen 1 (TIA1) in vivo …

Alzheimer's disease (AD) is characterized by progressive, age-dependent degeneration of
neurons in the central nervous system. A large body of evidence indicates that neurons …