[HTML][HTML] Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice

NL Gould, GR Scherer, S Carvalho… - The Journal of …, 2023 - Am Soc Clin Investig
Biological aging can be described as accumulative, prolonged metabolic stress and is the
major risk factor for cognitive decline and Alzheimer’s disease (AD). Recently, we identified …

Dopamine-dependent QR2 pathway activation in CA1 interneurons enhances novel memory formation

NL Gould, V Sharma, M Hleihil… - Journal of …, 2020 - Soc Neuroscience
The formation of memory for a novel experience is a critical cognitive capacity. The ability to
form novel memories is sensitive to age-related pathologies and disease, to which …

Somatostatin interneurons of the insula mediate QR2-dependent novel taste memory enhancement

NL Gould, SK Chandran, H Kayyal, E Edry… - ENeuro, 2021 - eneuro.org
Forming long-term memories is crucial for adaptive behavior and survival in changing
environments. The molecular consolidation processes which underlie the formation of these long-…

Muscarinic-dependent miR-182 and QR2 expression regulation in the anterior insula enables novel taste learning

NL Gould, A Elkobi, E Edry, J Daume, K Rosenblum - Eneuro, 2020 - eneuro.org
In a similar manner to other learning paradigms, intact muscarinic acetylcholine receptor (mAChR)
neurotransmission or protein synthesis regulation in the anterior insular cortex (aIC) …

[HTML][HTML] Improving the use of species distribution models in conservation planning and management under climate change

LL Porfirio, RMB Harris, EC Lefroy, S Hugh, SF Gould… - PLoS …, 2014 - journals.plos.org
Choice of variables, climate models and emissions scenarios all influence the results of
species distribution models under future climatic conditions. However, an overview of applied …

Ribosome subunits are upregulated in brain samples of a subgroup of individuals with schizophrenia: a systematic gene expression meta-analysis

…, A Yitzhaky, N Gould, K Rosenblum, L Hertzberg - Journal of Psychiatric …, 2023 - Elsevier
One of the new theories accounting for the underlying pathophysiology of schizophrenia is
excitation/inhibition imbalance. Interestingly, perturbation in protein synthesis machinery as …

A temporally‐restricted pattern of endothelial cell collagen 4 alpha 1 expression during embryonic development determined with a novel knockin Col4a1‐P2A‐eGFP …

NL Lartey, M van der Ent, R Alonzo, D Chen, PD King - genesis, 2024 - Wiley Online Library
Classical collagen type IV comprising of a heterotrimer of two collagen IV alpha 1 chains and
one collagen IV alpha 2 chain is the principal type of collagen synthesized by endothelial …

[BOOK][B] Grand Old Party: A History of the Republicans

L Gould - 2007 - books.google.com
… of the Republicans in 40 years, Lewis L. Gould traces the evolution of the Grand Old Party
Gould brings to life the major Þgures of Republican history--Lincoln, Theodore Roosevelt, …

[BOOK][B] The republicans: A history of the grand old party

LL Gould - 2014 - books.google.com
Lewis L. Gould's 2003 history of the Republican Party was a fast-paced account of … analysis
of Republican history, drawing on Gould's deep knowledge of the evolution of national …

Initial frequency of alleles for resistance to Bacillus thuringiensis toxins in field populations of Heliothis virescens

F Gould, A Anderson, A Jones… - Proceedings of the …, 1997 - National Acad Sciences
The risk of rapid pest adaptation to an insecticide is highly dependent on the initial frequency
of resistance alleles in field populations. Because we have lacked empirical estimates of …