User profiles for Naohisa Miyakawa

MIYAKAWA Naohisa

National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan
Verified email at umin.ac.jp
Cited by 797

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

Y Nagai, N Miyakawa, H Takuwa, Y Hori… - Nature …, 2020 - nature.com
The chemogenetic technology designer receptors exclusively activated by designer drugs (DREADDs)
afford remotely reversible control of cellular signaling, neuronal activity and …

[HTML][HTML] Chemogenetic attenuation of cortical seizures in nonhuman primates

N Miyakawa, Y Nagai, Y Hori, K Mimura… - Nature …, 2023 - nature.com
Epilepsy is a disorder in which abnormal neuronal hyperexcitation causes several types of
seizures. Because pharmacological and surgical treatments occasionally interfere with …

Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making

K Oyama, Y Hori, Y Nagai, N Miyakawa, K Mimura… - Science …, 2021 - science.org
The primate prefrontal cortex (PFC) is situated at the core of higher brain functions via neural
circuits such as those linking the caudate nucleus and mediodorsal thalamus. However, the …

[HTML][HTML] Intrasulcal electrocorticography in macaque monkeys with minimally invasive neurosurgical protocols

…, T Suzuki, M Shibata, N Miyakawa… - Frontiers in systems …, 2011 - frontiersin.org
Electrocorticography (ECoG), multichannel brain-surface recording and stimulation with probe
electrode arrays, has become a potent methodology not only for clinical neurosurgery but …

Intraoperative intrinsic optical imaging of neuronal activity from subdivisions of the human primary somatosensory cortex

…, S Sasaki, I Yazawa, H Mochida, N Miyakawa… - Cerebral …, 2002 - academic.oup.com
We performed intrinsic optical imaging of neuronal activity induced by peripheral stimulation
from the human primary somatosensory cortex during brain tumor surgery for 11 patients. …

[HTML][HTML] Chronic behavioral manipulation via orally delivered chemogenetic actuator in macaques

K Oyama, Y Hori, Y Nagai, N Miyakawa… - Journal of …, 2022 - Soc Neuroscience
The chemogenetic technology referred to as designer receptors exclusively activated by
designer drugs (DREADDs) offers reversible means to control neuronal activity for investigating …

Functional representation of the finger and face in the human somatosensory cortex: intraoperative intrinsic optical imaging

K Sato, T Nariai, Y Tanaka, T Maehara, N Miyakawa… - Neuroimage, 2005 - Elsevier
We applied the intrinsic optical imaging technique to the human primary somatosensory cortex
during brain tumor/epilepsy surgery for nine patients. The cortical surface was illuminated …

Chemogenetic disconnection between the orbitofrontal cortex and the rostromedial caudate nucleus disrupts motivational control of goal-directed action

…, MAG Eldridge, RC Saunders, N Miyakawa… - Journal of …, 2022 - Soc Neuroscience
The orbitofrontal cortex (OFC) and its major downstream target within the basal ganglia—the
rostromedial caudate nucleus (rmCD)—are involved in reward-value processing and goal-…

3D reconstruction of brain section images for creating axonal projection maps in marmosets

…, T Tani, H Mashiko, N Kitamura, N Miyakawa… - Journal of neuroscience …, 2017 - Elsevier
Background The brain of the common marmoset (Callithrix jacchus) is becoming a popular
non-human primate model in neuroscience research. Because its brain fiber connectivity is …

Optical imaging of intrinsic signals induced by peripheral nerve stimulation in the in vivo rat spinal cord

S Sasaki, I Yazawa, N Miyakawa, H Mochida… - Neuroimage, 2002 - Elsevier
We examined neural response patterns evoked by peripheral nerve stimulation in in vivo rat
spinal cords using an intrinsic optical imaging technique to monitor neural activity. Adult rats …