[HTML][HTML] FUS contributes to mTOR-dependent inhibition of translation

M Sévigny, IB Julien, JP Venkatasubramani… - Journal of Biological …, 2020 - ASBMB
The amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)–linked RNA-binding
protein called FUS (fused in sarcoma) has been implicated in several aspects of RNA …

[HTML][HTML] A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics

G Nicolas, M Sévigny, F Lecoquierre, F Marguet… - Acta neuropathologica …, 2022 - Springer
Frontotemporal dementia (FTD) is a heterogeneous clinical disorder characterized by progressive
abnormalities in behavior, executive functions, personality, language and/or motricity. …

[HTML][HTML] Girdin is a component of the lateral polarity protein network restricting cell dissemination

C Biehler, LT Wang, M Sévigny, A Jetté… - PLoS …, 2020 - journals.plos.org
Epithelial cell polarity defects support cancer progression. It is thus crucial to decipher the
functional interactions within the polarity protein network. Here we show that Drosophila Girdin …

NPRL2 inhibition of mTORC1 controls sodium channel expression and brain amino acid homeostasis

JB Hui, JCH Silva, MC Pelaez, M Sévigny… - Eneuro, 2022 - eneuro.org
Genetic mutations in nitrogen permease regulator-like 2 (NPRL2) are associated with a wide
spectrum of familial focal epilepsies, autism, and sudden unexpected death of epileptics (…

PDPR Gene Variants Predisposing to Papillary Thyroid Cancer

P Brock, M Sevigny, S Liyanarachchi, DF Comiskey Jr… - Thyroid, 2024 - liebertpub.com
Background: Papillary thyroid cancer (PTC) is the predominant subtype of thyroid cancer (THCA),
and it can cluster in families with an autosomal dominant (AD) inheritance pattern. The …

[HTML][HTML] Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation

…, SA Jones, Y Benchaar, J Bélanger, M Sévigny… - Journal of Biological …, 2023 - ASBMB
Heterozygous GRN (progranulin) mutations cause frontotemporal dementia (FTD) due to
haploinsufficiency, and increasing progranulin levels is a major therapeutic goal. Several …

[PDF][PDF] Implication de la protéine Girdin dans la polarité apico-basale des cellules épithéliales chez Drosophila melanogaster

M Sévigny - 2018 - corpus.ulaval.ca
La polarité apico-basale des cellules épithéliales est indispensable au maintien de l’intégrité
des tissus et sa dérégulation contribue à la progression tumorale. L’interaction antagoniste …

Antisense oligonucleotides targeting microRNA binding sites in the GRN mRNA increase progranulin translation: potential therapeutic strategy for frontotemporal …

…, G Aggarwal, Y Benchaar, J Bélanger, M Sévigny… - 2023 - ASPET
ID 24673 Poster Board 167 Heterozygous GRN mutations cause frontotemporal dementia (FTD)
due to haploinsufficiency of progranulin. The microRNA, miR-29b, negatively regulates …

Antisense oligonucleotides targeting miR‐29b binding site increase translation of progranulin protein: potential therapeutic strategy for progranulin‐deficient …

…, Y Benchaar, J Bélanger, M Sévigny… - Alzheimer's & …, 2022 - Wiley Online Library
Background GRN mutations cause frontotemporal dementia (FTD) due to haploinsufficiency
of progranulin. Several microRNAs (miRs), including miR‐29b, have been reported to …

[PDF][PDF] https://www. jbc. org/cgi/doi/10.1074/jbc. RA120. 013801 The latest version is at

M Sévigny, IB Julien, JP Venkatasubramani, JB Hui… - proteins - researchgate.net
The amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD)-linked RNA-binding
protein called fused in sarcoma (FUS) has been implicated in several aspects of …