[HTML][HTML] FUS contributes to mTOR-dependent inhibition of translation
M Sévigny, IB Julien, JP Venkatasubramani… - Journal of Biological …, 2020 - ASBMB
The amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)–linked RNA-binding
protein called FUS (fused in sarcoma) has been implicated in several aspects of RNA …
protein called FUS (fused in sarcoma) has been implicated in several aspects of RNA …
[HTML][HTML] A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics
G Nicolas, M Sévigny, F Lecoquierre, F Marguet… - Acta neuropathologica …, 2022 - Springer
Frontotemporal dementia (FTD) is a heterogeneous clinical disorder characterized by progressive
abnormalities in behavior, executive functions, personality, language and/or motricity. …
abnormalities in behavior, executive functions, personality, language and/or motricity. …
[HTML][HTML] Girdin is a component of the lateral polarity protein network restricting cell dissemination
C Biehler, LT Wang, M Sévigny, A Jetté… - PLoS …, 2020 - journals.plos.org
Epithelial cell polarity defects support cancer progression. It is thus crucial to decipher the
functional interactions within the polarity protein network. Here we show that Drosophila Girdin …
functional interactions within the polarity protein network. Here we show that Drosophila Girdin …
NPRL2 inhibition of mTORC1 controls sodium channel expression and brain amino acid homeostasis
Genetic mutations in nitrogen permease regulator-like 2 (NPRL2) are associated with a wide
spectrum of familial focal epilepsies, autism, and sudden unexpected death of epileptics (…
spectrum of familial focal epilepsies, autism, and sudden unexpected death of epileptics (…
PDPR Gene Variants Predisposing to Papillary Thyroid Cancer
P Brock, M Sevigny, S Liyanarachchi, DF Comiskey Jr… - Thyroid, 2024 - liebertpub.com
Background: Papillary thyroid cancer (PTC) is the predominant subtype of thyroid cancer (THCA),
and it can cluster in families with an autosomal dominant (AD) inheritance pattern. The …
and it can cluster in families with an autosomal dominant (AD) inheritance pattern. The …
[HTML][HTML] Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation
…, SA Jones, Y Benchaar, J Bélanger, M Sévigny… - Journal of Biological …, 2023 - ASBMB
Heterozygous GRN (progranulin) mutations cause frontotemporal dementia (FTD) due to
haploinsufficiency, and increasing progranulin levels is a major therapeutic goal. Several …
haploinsufficiency, and increasing progranulin levels is a major therapeutic goal. Several …
[PDF][PDF] Implication de la protéine Girdin dans la polarité apico-basale des cellules épithéliales chez Drosophila melanogaster
M Sévigny - 2018 - corpus.ulaval.ca
La polarité apico-basale des cellules épithéliales est indispensable au maintien de l’intégrité
des tissus et sa dérégulation contribue à la progression tumorale. L’interaction antagoniste …
des tissus et sa dérégulation contribue à la progression tumorale. L’interaction antagoniste …
Antisense oligonucleotides targeting microRNA binding sites in the GRN mRNA increase progranulin translation: potential therapeutic strategy for frontotemporal …
…, G Aggarwal, Y Benchaar, J Bélanger, M Sévigny… - 2023 - ASPET
ID 24673 Poster Board 167 Heterozygous GRN mutations cause frontotemporal dementia (FTD)
due to haploinsufficiency of progranulin. The microRNA, miR-29b, negatively regulates …
due to haploinsufficiency of progranulin. The microRNA, miR-29b, negatively regulates …
Antisense oligonucleotides targeting miR‐29b binding site increase translation of progranulin protein: potential therapeutic strategy for progranulin‐deficient …
…, Y Benchaar, J Bélanger, M Sévigny… - Alzheimer's & …, 2022 - Wiley Online Library
Background GRN mutations cause frontotemporal dementia (FTD) due to haploinsufficiency
of progranulin. Several microRNAs (miRs), including miR‐29b, have been reported to …
of progranulin. Several microRNAs (miRs), including miR‐29b, have been reported to …
[PDF][PDF] https://www. jbc. org/cgi/doi/10.1074/jbc. RA120. 013801 The latest version is at
M Sévigny, IB Julien, JP Venkatasubramani, JB Hui… - proteins - researchgate.net
The amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD)-linked RNA-binding
protein called fused in sarcoma (FUS) has been implicated in several aspects of …
protein called fused in sarcoma (FUS) has been implicated in several aspects of …