Asf1 is a conserved histone chaperone implicated in nucleosome assembly, transcriptional
silencing, and the cellular response to DNA damage. We solved the NMR solution structure …

Most membrane proteins studies require the use of detergents, but because of the lack of a
general, accurate and rapid method to quantify them, many uncertainties remain that hamper …

KCC2 is a neuron specific K + -Cl − co-transporter that controls neuronal chloride
homeostasis, and is critically involved in many neurological diseases including brain trauma, …

We present an automated microfluidic platform that performs multisecond observation of
single molecules with millisecond time resolution while bypassing the need for immobilization …

Translationally Controlled Tumor Protein (TCTP) is anti-apoptotic, key in development and
cancer, however without the typical Bcl2 family members’ structure. Here we report that TCTP …

Asf1 is a histone chaperone that favors histone H3/H4 assembly and disassembly. We
solved the structure of the conserved domain of human ASF1A in complex with the C-terminal …

Histone chaperones have been implicated in nucleosome assembly and disassembly as
well as histone modification. ASF1 is a highly conserved histone H3/H4 chaperone that …

Membrane proteins play crucial role in many cellular processes including cell adhesion, cell-cell
communication, signal transduction and transport. To better understand the molecular …

A plethora of neurological disorders are associated with alterations in the expression and
localization of potassium-chloride cotransporter type 2 (KCC2), making KCC2 a critical player …

CD20 is a B-lymphocyte specific integral membrane protein, an activated-glycosylated
phosphoprotein expressed on the surface of B-cells and a clinically validated target of …