Exposure to stressors can enhance neuroinflammatory responses, and both stress and
neuroinflammation are predisposing factors in the development of psychiatric disorders. Females …

Hippocampal microglia are vulnerable to the effects of aging, displaying a primed phenotype
and hyper-responsiveness to various stimuli. We have previously shown that short-term …

Spinal cord injury (SCI) elicits chronic pain in 65% of individuals. In addition, SCI afflicts an
increasing number of aged individuals, and those with SCI are predisposed to shorter lifespan…

Spinal cord injury (SCI) causes chronic pain in 65% of individuals. Unfortunately, current pain
management is inadequate for many SCI patients. Rodent models could help identify how …

Spinal cord injury (SCI) perturbs many physiological systems. The circadian system helps
maintain homeostasis throughout the body by synchronizing physiological and behavioral …

Spinal cord injury (SCI) dysregulates metabolic homeostasis. Metabolic homeostasis is
optimized across the day by the circadian system. Despite the prevalence of metabolic …

We have developed an efficient, reproducible, and scaleable cell culture process for a
recombinant adenoviral vector expressing therapeutic transgenes for clinical trials. HEK 293 cells …

Several known process monitoring methods were tested for their efficacy in the detection of
adenovirus infections. The methods that we explored include several indirect indications of …

Large-scale mammalian cell culture is frequently performed in stirred tank or airlift reactors
in batch mode, and to achieve high cell densities and product concentrations fed-batch …

The mechanisms behind the induction of malignancy and chemoresistance in breast cancer
cells are still not completely understood. Inflammation is associated with the induction of …