Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice
P Clément-Lacroix, M Ai, F Morvan… - Proceedings of the …, 2005 - National Acad Sciences
One of the well characterized cell biologic actions of lithium is the inhibition of glycogen
synthase kinase-3β and the consequent activation of canonical Wnt signaling. Because deficient …
synthase kinase-3β and the consequent activation of canonical Wnt signaling. Because deficient …
[HTML][HTML] The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment
K Sawakami, AG Robling, M Ai, ND Pitner, D Liu… - Journal of Biological …, 2006 - ASBMB
The cell surface receptor, low-density lipoprotein receptor-related protein 5 (LRP5) is a key
regulator of bone mass. Loss-of-function mutations in LRP5 cause the human skeletal …
regulator of bone mass. Loss-of-function mutations in LRP5 cause the human skeletal …
Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6
…, JF Hess, V Glatt, ML Bouxsein, M Ai… - Journal of Bone and …, 2004 - academic.oup.com
Humans and mice lacking Lrp5 have low BMD. To evaluate whether Lrp5 and Lrp6 interact
genetically to control bone or skeletal development, we created mice carrying mutations in …
genetically to control bone or skeletal development, we created mice carrying mutations in …
Acid sensing by the Drosophila olfactory system
The odour of acids has a distinct quality that is perceived as sharp, pungent and often
irritating 1 . How acidity is sensed and translated into an appropriate behavioural response is …
irritating 1 . How acidity is sensed and translated into an appropriate behavioural response is …
Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt …
M Ai, SL Holmen, W Van Hul, BO Williams… - … and cellular biology, 2005 - Taylor & Francis
The low-density-lipoprotein receptor-related protein 5 (LRP5), a coreceptor in the canonical
Wnt signaling pathway, has been implicated in human disorders of low and high bone mass. …
Wnt signaling pathway, has been implicated in human disorders of low and high bone mass. …
Dedicated olfactory neurons mediating attraction behavior to ammonia and amines in Drosophila
Animals across various phyla exhibit odor-evoked innate attraction behavior that is
developmentally programmed. The mechanism underlying such behavior remains unclear because …
developmentally programmed. The mechanism underlying such behavior remains unclear because …
[PDF][PDF] Clinical and molecular findings in osteoporosis-pseudoglioma syndrome
M Ai, S Heeger, CF Bartels, DK Schelling - The American Journal of …, 2005 - cell.com
Mutations in the low-density lipoprotein receptor–related protein 5 gene (LRP5) cause
autosomal recessive osteoporosis-pseudoglioma syndrome (OPPG). We sequenced the coding …
autosomal recessive osteoporosis-pseudoglioma syndrome (OPPG). We sequenced the coding …
Ionotropic glutamate receptors IR64a and IR8a form a functional odorant receptor complex in vivo in Drosophila
Drosophila olfactory sensory neurons express either odorant receptors or ionotropic glutamate
receptors (IRs). The sensory neurons that express IR64a, a member of the IR family, send …
receptors (IRs). The sensory neurons that express IR64a, a member of the IR family, send …
The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations
W Balemans, E Piters, E Cleiren, M Ai… - Calcified tissue …, 2008 - Springer
Low-density lipoprotein receptor–related protein 5 (LRP5), a Wnt coreceptor, plays an
important role in bone metabolism as loss-of-function and gain-of-function mutations in LRP5 …
important role in bone metabolism as loss-of-function and gain-of-function mutations in LRP5 …
GIP receptor agonism attenuates GLP-1 receptor agonist–induced nausea and emesis in preclinical models
Glucagon-like peptide 1 receptor (GLP-1R) agonists decrease body weight and improve
glycemic control in obesity and diabetes. Patient compliance and maximal efficacy of GLP-1 …
glycemic control in obesity and diabetes. Patient compliance and maximal efficacy of GLP-1 …