User profiles for Mikaela A. Laine

Mikaela A Laine

Lecturer in Neuroscience and Psychology
Verified email at smith.edu
Cited by 420

[HTML][HTML] Brain activation induced by chronic psychosocial stress in mice

MA Laine, E Sokolowska, M Dudek, SA Callan… - Scientific reports, 2017 - nature.com
Chronic psychosocial stress is a well-established risk factor for neuropsychiatric diseases.
Abnormalities in brain activity have been demonstrated in patients with stress-related …

Genetic control of myelin plasticity after chronic psychosocial stress

MA Laine, K Trontti, Z Misiewicz, E Sokolowska… - eneuro, 2018 - eneuro.org
Anxiety disorders often manifest in genetically susceptible individuals after psychosocial
stress, but the mechanisms underlying these gene-environment interactions are largely …

[HTML][HTML] Multi-omics analysis identifies mitochondrial pathways associated with anxiety-related behavior

…, G Maccarrone, J Martins, D Czamara, MA Laine… - PLoS …, 2019 - journals.plos.org
Stressful life events are major environmental risk factors for anxiety disorders, although not
all individuals exposed to stress develop clinical anxiety. The molecular mechanisms …

Darting across space and time: parametric modulators of sex-biased conditioned fear responses

…, M Fanikos, E Golden, MA Laine… - Learning & …, 2022 - learnmem.cshlp.org
Pavlovian fear conditioning is a widely used behavioral paradigm for studying associative
learning in rodents. Despite early recognition that subjects may engage in a variety of both …

Sounding the alarm: sex differences in rat ultrasonic vocalizations during Pavlovian fear conditioning and extinction

MA Laine, JR Mitchell, J Rhyner, R Clark, A Kannan… - ENeuro, 2022 - eneuro.org
Pavlovian fear conditioning is a prevalent tool in the study of aversive learning, which is a
key component of stress-related psychiatric disorders. Adult rats can exhibit various threat-…

[HTML][HTML] CB1R blockade unmasks TRPV1-mediated contextual fear generalization in female, but not male rats

…, M Mejdell, A Singh, V Bhutani, MA Laine… - …, 2023 - nature.com
Increasing evidence suggests that the neurobiological processes that govern learning and
memory can be different in males and females, but many of the specific mechanisms …

Genetic variants associated with anxiety and stress-related disorders: a genome-wide association study and mouse-model study

…, K Trontti, KL Purves, TD Als, J Grove, M Laine… - JAMA …, 2019 - jamanetwork.com
Importance Anxiety and stress-related disorders are among the most common mental
disorders. Although family and twin studies indicate that both genetic and environmental factors …

[HTML][HTML] Node of Ranvier remodeling in chronic psychosocial stress and anxiety

MK Koskinen, M Laine, A Abdollahzadeh… - …, 2023 - nature.com
Differential expression of myelin-related genes and changes in myelin thickness have been
demonstrated in mice after chronic psychosocial stress, a risk factor for anxiety disorders. To …

Genome-wide association study of anxiety and stress-related disorders in the iPSYCH cohort

SM Meier, K Trontti, TD Als, M Laine, MG Pedersen… - BioRxiv, 2018 - biorxiv.org
Anxiety and stress-related disorders (ASRD) are among the most common mental disorders
with the majority of patients suffering from additional disorders. Family and twin studies …

Gene-environment interaction in myelin plasticity after chronic psychosocial stress

MA Laine, K Trontti, Z Misiewicz, E Sokolowska… - European …, 2019 - ecnp.eu
Background Mikaela A Laine1, Kalevi Trontti1, Zuzanna Misiewicz1, Ewa Sokolowska1,
Eva Rikandi2, 3, 4, Natalia Kulesskaya1, Aino Heikkinen1, Suvi Saarnio1, Ingrid Balcells1, …