The effects of local application of D2 selective dopaminergic drugs into the medial prefrontal cortex of rats in a delayed spatial choice task

MY Druzin, NP Kurzina, EP Malinina… - Behavioural brain …, 2000 - Elsevier
The study examined the effects of modulation of dopamine D2 receptors-mediated
neurotransmission in the rat’s prefrontal cortex (PFC) on storage and executive components of …

Cl concentration changes and desensitization of GABAA and glycine receptors

U Karlsson, M Druzin, S Johansson - Journal of General Physiology, 2011 - rupress.org
Desensitization of ligand-gated ion channels plays a critical role for the information transfer
between neurons. The current view on γ-aminobutyric acid (GABA) A and glycine receptors …

[HTML][HTML] Medroxyprogesterone acetate positively modulates specific GABAA-receptor subtypes-affecting memory and cognition

…, J Sjöstedt, M Johansson, D Haage, M Druzin… - …, 2022 - Elsevier
Medroxyprogesterone acetate (MPA) is a progestin widely used in humans as hormone
replacement therapy and at other indications. Many progestin metabolites, as the progesterone …

The functional role of a bicuculline‐sensitive Ca2+‐activated K+ current in rat medial preoptic neurons

S Johansson, M Druzin, D Haage… - The Journal of …, 2001 - Wiley Online Library
1 A Ca 2+ ‐activated K + current was identified in neurons from the rat medial preoptic nucleus.
Its functional role for the resting potential and for impulse generation was characterised …

Allopregnanolone modulates spontaneous GABA release via presynaptic Cl− permeability in rat preoptic nerve terminals

D Haage, M Druzin, S Johansson - Brain research, 2002 - Elsevier
The endogenous neurosteroid 3α-hydroxy-5α-pregnane-20-one (allopregnanolone) affects
presynaptic nerve terminals and thereby increases the frequency of spontaneous GABA …

[HTML][HTML] Mechanism of Estradiol-Induced Block of Voltage-Gated K+ Currents in Rat Medial Preoptic Neurons

M Druzin, E Malinina, O Grimsholm, S Johansson - PloS one, 2011 - journals.plos.org
The present study was conducted to characterize possible rapid effects of 17-β-estradiol on
voltage-gated K + channels in preoptic neurons and, in particular, to identify the mechanisms …

Contribution of resting conductance, GABAA-receptor mediated miniature synaptic currents and neurosteroid to chloride homeostasis in central neurons

TD Yelhekar, M Druzin, S Johansson - Eneuro, 2017 - eneuro.org
Maintenance of a low intraneuronal Cl – concentration, [Cl – ] i , is critical for inhibition in the
CNS. Here, the contribution of passive, conductive Cl – flux to recovery of [Cl – ] i after a …

[HTML][HTML] How to Properly Measure a Current-Voltage Relation?—Interpolation vs. Ramp Methods Applied to Studies of GABAA Receptors

TD Yelhekar, M Druzin, U Karlsson… - Frontiers in cellular …, 2016 - frontiersin.org
The relation between current and voltage, IV relation, is central to functional analysis of
membrane ion channels. A commonly used method, since the introduction of the voltage-clamp …

[HTML][HTML] Heparan Sulfates Regulate Axonal Excitability and Context Generalization through Ca2+/Calmodulin-Dependent Protein Kinase II

…, O Senkov, H Hayani, A Mironov, R Kaushik, M Druzin… - Cells, 2023 - mdpi.com
Our previous studies demonstrated that enzymatic removal of highly sulfated heparan sulfates
with heparinase 1 impaired axonal excitability and reduced expression of ankyrin G at the …

Dual and opposing roles of presynaptic Ca2+ influx for spontaneous GABA release from rat medial preoptic nerve terminals

M Druzin, D Haage, E Malinina… - The Journal of …, 2002 - Wiley Online Library
Calcium influx into the presynaptic nerve terminal is well established as a trigger signal for
transmitter release by exocytosis. By studying dissociated preoptic neurons with functional …