Dravet syndrome is a catastrophic pediatric epilepsy with severe intellectual disability, impaired
social development and persistent drug-resistant seizures. One of its primary monogenic …

Despite a long tradition of using rats and mice to model epilepsy, several aspects of rodent
biology limit their use in large-scale genetic and therapeutic drug screening programs. …

Methods: Seizures were induced with pentylenetetrazole (PTZ). Zebrafish were analyzed
between 3 and 7 days postfertilization (dpf). Genome mutations were induced in founders by …

Mutations in a voltage-gated sodium channel (SCN1A) result in Dravet Syndrome (DS), a
catastrophic childhood epilepsy. Zebrafish with a mutation in scn1Lab recapitulate salient …

Disruption of E3 ubiquitin ligase activity in immature zebrafish mind bomb mutants leads to
a failure in Notch signaling, excessive numbers of neurons, and depletion of neural …

Genetic engineering techniques have contributed to the now widespread use of zebrafish to
investigate gene function, but zebrafish-based human disease studies, and particularly for …

Altered metabolism is an important feature of many epileptic syndromes but has not been
reported in Dravet syndrome (DS), a catastrophic childhood epilepsy associated with …

Members of the K v 7 family generate a subthreshold potassium current, termed M‐current,
that regulates the excitability of principal central neurons. Mutations in two members of this …

Energy-producing pathways are novel therapeutic targets for the treatment of neurodevelopmental
disorders. Here, we focussed on correcting metabolic defects in a catastrophic …

Purpose: In patients with tuberous sclerosis complex (TSC), a wide range of neurologic
abnormalities develop, including mental retardation and seizures. Brains from TSC patients are …