The most important problem still remaining is the identification of the downstream targets of
GTP-binding proteins. Except for a few cases, the assignment of functions for each individual …

Adult neurogenesis in the mammalian brain is often viewed as a continuation of neurogenesis
at earlier, developmental stages. Here, we will critically review the extent to which this is …

The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation,
which results in contraction of smooth muscle and interaction of actin and myosin in …

The adult brain is extremely vulnerable to various insults. The recent discovery of neural
progenitors in adult mammals, however, raises the possibility of repairing damaged tissue by …

The small GTP binding protein Rho is implicated in cytoskeletal responses to extracellular
signals such as lysophosphatidic acid to form stress fibers and focal contacts. Here we have …

Radial glial cells, ubiquitous throughout the developing CNS, guide radially migrating neurons
and are the precursors of astrocytes. Recent evidence indicates that radial glial cells also …

Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling in vertebrates.
The question remains unanswered, however, as to how these Gli proteins participate in …

The floor plate plays important roles in ventral pattern formation and axonal guidance within
the neural tube of vertebrate embryos. A critical event for floor plate development is the …

Drosophila transcription factorcubitus interruptus (Ci) and its co-activator CRE (cAMP
response element)-binding protein (CBP) activate a group of target genes on the anterior-posterior …

Musashi1 (Msi1) is an RNA-binding protein that is highly expressed in neural progenitor
cells, including neural stem cells. In this study, the RNA-binding sequences for Msi1 were …