Functional magnetic resonance imaging (fMRI) is a valuable method for probing postnatal
circuit refinement and plasticity. However, its use during early development has been …

Highlights • A switch in thalamocortical dynamics defines ‘pre-sensory’and ‘sensory’stages.
• Pre-sensory networks prioritize detection at the expense of discrimination. • A thalamic …

Children with Fragile X syndrome (FXS) have deficits of attention and arousal. To begin to
identify the neural causes of these deficits, we examined juvenile rats lacking the Fragile X …

Many ligands that affect nervous system development are members of gene families that
function together to coordinate the assembly of complex neural circuits. cpg15/neuritin encodes …

Fragile X syndrome (FXS) is characterized by sensory hyper-sensitivity, and animal models
suggest that neuronal hyper-excitability contributes to this phenotype. To understand how …

The isocortex of all mammals studied to date shows a progressive increase in the amount
and continuity of background activity during early development. In humans the transition from …

N-methyl-d-aspartate receptors (NMDARs) have been linked to schizophrenia because
agents that bind the receptor, like ketamine and phencyclidine, are capable of inducing …

The visual layers of the rodent superficial superior colliculus (sSC) have been the focus of
many development studies of the molecular bases of retinotopic map formation, the role of …

The mechanisms by which experience guides refinement of converging afferent pathways
are poorly understood. We describe a vision-driven refinement of corticocollicular inputs that …

In this issue of Neuron, Ibrahim et al. (2021) examine the rules by which top-down
connections are made on visual cortical layer 1 interneurons, discovering activity-dependent …