User profiles for Markus M. Hilscher

Markus M. Hilscher

Science for Life Laboratory, SE
Verified email at roche.com
Cited by 1786

Spatiotemporal structure of cell fate decisions in murine neural crest

…, M Farlik, ML Piacentino, F Boismoreau, MM Hilscher… - Science, 2019 - science.org
Neural crest cells are embryonic progenitors that generate numerous cell types in vertebrates.
With single-cell analysis, we show that mouse trunk neural crest cells become biased …

[HTML][HTML] A community-based transcriptomics classification and nomenclature of neocortical cell types

…, S Herculano-Houzel, MM Hilscher… - Nature …, 2020 - nature.com
To understand the function of cortical circuits, it is necessary to catalog their cellular diversity.
Past attempts to do so using anatomical, physiological or molecular features of cortical …

[HTML][HTML] Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development

…, L Gillberg, N Volakakis, C Yokota, MM Hilscher… - Nature …, 2019 - nature.com
Midbrain dopamine (mDA) neurons constitute a heterogenous group of cells that have been
intensely studied, not least because their degeneration causes major symptoms in …

Hybridization-based in situ sequencing (HybISS) for spatially resolved transcriptomics in human and mouse brain tissue

…, MM Hilscher, ES Lein, M Nilsson - Nucleic acids …, 2020 - academic.oup.com
Visualization of the transcriptome in situ has proven to be a valuable tool in exploring single-cell
RNA-sequencing data, providing an additional spatial dimension to investigate …

[HTML][HTML] Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

…, S Zhang, D van Bruggen, MM Hilscher… - Nature …, 2020 - nature.com
Mature oligodendrocytes (MOLs) show transcriptional heterogeneity, the functional consequences
of which are unclear. MOL heterogeneity might correlate with the local environment or …

[HTML][HTML] Chrna2-Martinotti cells synchronize layer 5 type A pyramidal cells via rebound excitation

MM Hilscher, RN Leão, SJ Edwards, KE Leão… - PLoS …, 2017 - journals.plos.org
Martinotti cells are the most prominent distal dendrite–targeting interneurons in the cortex,
but their role in controlling pyramidal cell (PC) activity is largely unknown. Here, we show that …

Placing RNA in context and space–methods for spatially resolved transcriptomics

C Strell, MM Hilscher, N Laxman, J Svedlund… - The FEBS …, 2019 - Wiley Online Library
Single‐cell transcriptomics provides us with completely new insights into the molecular
diversity of different cell types and the different states they can adopt. The technique generates …

[PDF][PDF] OLMα2 cells bidirectionally modulate learning

…, ASC Franca, S Mikulovic, A Reis, MM Hilscher… - Neuron, 2018 - cell.com
Inhibitory interneurons participate in mnemonic processes. However, defined roles for identified
interneuron populations are scarce. A subpopulation of oriens lacunosum-moleculare (…

[HTML][HTML] Spatial and temporal heterogeneity in the lineage progression of fine oligodendrocyte subtypes

MM Hilscher, CM Langseth, P Kukanja, C Yokota… - BMC biology, 2022 - Springer
Background Oligodendrocytes are glial cells that support and insulate axons in the central
nervous system through the production of myelin. Oligodendrocytes arise throughout …

Characterization of Dmrt3-derived neurons suggest a role within locomotor circuits

…, J Vieillard, C Nagaraja, MM Hilscher… - Journal of …, 2019 - Soc Neuroscience
Neuronal networks within the spinal cord, collectively known as the central pattern generator
(CPG), coordinate rhythmic movements underlying locomotion. The transcription factor …