Experimental models of peripheral nerve injury have been developed to study mechanisms
of neuropathic pain. In the spared nerve injury (SNI) model in rats, the common peroneal …

Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural
circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, …

Background Gene transfer to nociceptive neurons of the dorsal root ganglia (DRG) is a
promising approach to dissect mechanisms of pain in rodents and is a potential therapeutic …

Voltage-gated sodium channel (Na v 1) β2 subunits modulate channel gating, assembly,
and cell-surface expression in CNS neurons in vitro and in vivo. β2 expression increases in …

Peripheral neuropathic pain is a disabling condition resulting from nerve injury. It is characterized
by the dysregulation of voltage-gated sodium channels (Na v s) expressed in dorsal …

Background Current evidence indicates that p38 mitogen-activated protein kinase activation
in spinal microglia contributes to the development of neuropathic pain. However, how nerve …

Changes in expression and function of voltage-gated sodium channels (VGSC) in dorsal
root ganglion (DRG) neurons may play a major role in the genesis of peripheral …

The development of abnormal primary sensory neuron excitability and neuropathic pain
symptoms after peripheral nerve injury is associated with altered expression of voltage-gated …

Background: Dysregulation of voltage-gated sodium channels (Na v s) is believed to play a
major role in nerve fiber hyperexcitability associated with neuropathic pain. A complete …

Voltage-gated sodium channels (Na v s) are glycoproteins composed of a pore-forming α-subunit
and associated β-subunits that regulate Na v α-subunit plasma membrane density and …