Synapsin regulation of vesicle organization and functional pools

M Bykhovskaia - Seminars in cell & developmental biology, 2011 - Elsevier
Synaptic vesicles are organized in clusters, and synapsin maintains vesicle organization and
abundance in nerve terminals. At the functional level, vesicles can be subdivided into three …

Synapsin regulates activity-dependent outgrowth of synaptic boutons at the Drosophila neuromuscular junction

…, D Volfson, JT Littleton, M Bykhovskaia - Journal of …, 2014 - Soc Neuroscience
Patterned depolarization of Drosophila motor neurons can rapidly induce the outgrowth of
new synaptic boutons at the larval neuromuscular junction (NMJ), providing a model system to …

Synapsin maintains the reserve vesicle pool and spatial segregation of the recycling pool in Drosophila presynaptic boutons

Y Akbergenova, M Bykhovskaia - Brain research, 2007 - Elsevier
We employed optical detection of the lipophylic dye FM1-43 and focal recordings of quantal
release to investigate how synapsin affects vesicle cycling at the neuromuscular junction of …

Regulation of transmitter release by synapsin II in mouse motor terminals

…, CA Bill, WL Coleman, M Bykhovskaia - The Journal of …, 2004 - Wiley Online Library
We investigated quantal release and ultrastructure in the neuromuscular junctions of
synapsin II knockout (Syn II KO) mice. Synaptic responses were recorded focally from the …

A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca2+ cooperativity of vesicle fusion

Z Guan, M Bykhovskaia, RA Jorquera, RB Sutton… - Elife, 2017 - elifesciences.org
10.7554/eLife.28409.001 The synaptic vesicle Ca 2+ sensor Synaptotagmin binds Ca 2+
through its two C2 domains to trigger membrane interactions. Beyond membrane insertion by …

Sub-millimetre wave absorption spectra of artificial RNA molecules

T Globus, M Bykhovskaia, D Woolard… - Journal of Physics D …, 2003 - iopscience.iop.org
We demonstrate submillimetre-wave Fourier transform spectroscopy as a novel technique
for biological molecule characterization. Transmission measurements are reported at …

Facilitation at the lobster neuromuscular junction: a stimulus-dependent mobilization model

MK Worden, M Bykhovskaia… - Journal of …, 1997 - journals.physiology.org
Worden, Mary Kate, Maria Bykhovskaia, and John T. Hackett. Facilitation at the lobster
neuromuscular junction: a stimulus-dependent mobilization model. J. Neurophysiol. 78: 417–428, …

[HTML][HTML] Interaction of the complexin accessory helix with the C-terminus of the SNARE complex: molecular-dynamics model of the fusion clamp

M Bykhovskaia, A Jagota, A Gonzalez, A Vasin… - Biophysical journal, 2013 - cell.com
SNARE complexes form between the synaptic vesicle protein synaptobrevin and the plasma
membrane proteins syntaxin and SNAP25 to drive membrane fusion. A cytosolic protein, …

Adar is essential for optimal presynaptic function

…, D Alicea, M Gonzalez, M Bykhovskaia… - Molecular and Cellular …, 2013 - Elsevier
RNA editing is a powerful way to recode genetic information. Because it potentially affects
RNA targets that are predominantly present in neurons, it is widely hypothesized to affect …

Prediction of DNA far-IR absorption spectra based on normal mode analysis

M Bykhovskaia, B Gelmont, T Globus… - Theoretical Chemistry …, 2001 - Springer
We present a computational method which couples normal mode analysis in internal
coordinates of a molecule with very far IR spectroscopy. The analytical expression for the …