The human multidrug resistance-associated protein (MRP) family currently has seven
members. The ability of several of these membrane proteins to transport a wide range of …

The human multidrug resistance protein (MRP) family contains at least six members: MRP1,
the godfather of the family and well known as the multidrug resistance protein, and five …

The division of medulloblastoma into different subgroups by microarray expression profiling
has dramatically changed our perspective of this malignant childhood brain tumour. Now, …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

Accurate pathological diagnosis is crucial for optimal management of patients with cancer.
For the approximately 100 known tumour types of the central nervous system, standardization …

Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However,
DNA copy number and gene expression signatures indicate differences between adult and …

Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of morbidity
and mortality in pediatric oncology. Current mechanisms for clinical prognostication and …

Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable
heterogeneity. We have recently identified recurrent H3F3A mutations affecting two …

By screening databases of human expressed sequence tags, we have identified three new
homologues of MRP1, the gene encoding the multidrug resistance-associated protein, and …

Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …