Many biological and neural systems can be seen as networks of interacting periodic processes.
Importantly, their functionality, ie, whether these networks can perform their function or …

Surgery is a valuable option for pharmacologically intractable epilepsy. However, significant
post-operative improvements are not always attained. This is due in part to our incomplete …

Generalised epileptic seizures are frequently accompanied by sudden, reversible
transitions from low amplitude, irregular background activity to high amplitude, regular spike–wave …

Active brain stimulation to abate epileptic seizures has shown mixed success. In spike-wave
(SW) seizures, where the seizure and background state were proposed to coexist, single-…

The dynamics of the resting brain exhibit transitions between a small number of discrete
networks, each remaining stable for tens to hundreds of milliseconds. These functional …

Surgery is a therapeutic option for people with epilepsy whose seizures are not controlled
by anti-epilepsy drugs. In pre-surgical planning, an array of data modalities, often including …

Stimulation of human epileptic tissue can induce rhythmic, self-terminating responses on
the EEG or ECoG. These responses play a potentially important role in localising tissue …

Recent clinical work has implicated network structure as critically important in the initiation
of seizures in people with idiopathic generalized epilepsies. In line with this idea, functional …

The occurrence of seizures is the common feature across the spectrum of epileptic disorders.
We describe how the use of mechanistic neural population models leads to novel insight …

Recent experimental and clinical studies have provided diverse insight into the mechanisms
of human focal seizure initiation and propagation. Often these findings exist at different …