User profiles for Malcolm J. Low
Malcolm Low OR Malcolm J Low OR MJ LowUniversity of Michigan Verified email at umich.edu Cited by 31300 |
Central serotonin and melanocortin pathways regulating energy homeostasis
…, T Kishi, LH Tecott, W Fan, MJ Low… - Annals of the New …, 2003 - Wiley Online Library
It is now established that the hypothalamus is essential in coordinating endocrine, autonomic,
and behavioral responses to changes in energy availability. However, the interaction of …
and behavioral responses to changes in energy availability. However, the interaction of …
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
The administration of leptin 1 to leptin-deficient humans, and the analogous Lep ob /Lep ob
mice, effectively reduces hyperphagia and obesity 2 , 3 . But common obesity is associated …
mice, effectively reduces hyperphagia and obesity 2 , 3 . But common obesity is associated …
Gut hormone PYY3-36 physiologically inhibits food intake
…, MA Cohen, CL Dakin, AM Wren, AE Brynes, MJ Low… - Nature, 2002 - nature.com
Food intake is regulated by the hypothalamus, including the melanocortin and neuropeptide
Y (NPY) systems in the arcuate nucleus 1 . The NPY Y2 receptor (Y2R), a putative inhibitory …
Y (NPY) systems in the arcuate nucleus 1 . The NPY Y2 receptor (Y2R), a putative inhibitory …
[PDF][PDF] The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
The gastrointestinal peptide hormone ghrelin stimulates appetite in rodents and humans via
hypothalamic actions. We discovered expression of ghrelin in a previously uncharacterized …
hypothalamic actions. We discovered expression of ghrelin in a previously uncharacterized …
[HTML][HTML] Unraveling the central proopiomelanocortin neural circuits
…, ST Hentges, CK Meshul, MJ Low - Frontiers in …, 2013 - frontiersin.org
Central proopiomelanocortin (POMC) neurons form a potent anorexigenic network, but our
understanding of the integration of this hypothalamic circuit throughout the central nervous …
understanding of the integration of this hypothalamic circuit throughout the central nervous …
Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.
KG Mountjoy, MT Mortrud, MJ Low… - Molecular …, 1994 - academic.oup.com
POMC, the precursor of ACTH, MSH, and beta-endorphin peptides, is expressed in the
pituitary and in two sites in the brain, in the arcuate nucleus of the hypothalamus and the …
pituitary and in two sites in the brain, in the arcuate nucleus of the hypothalamus and the …
Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.
…, LS Robbins, MT Mortrud, MJ Low… - Proceedings of the …, 1993 - National Acad Sciences
Corticotropin (ACTH) and melanotropin (MSH) peptides (melanocortins) are produced not
only in the pituitary but also in the brain, with highest concentrations in the arcuate nucleus of …
only in the pituitary but also in the brain, with highest concentrations in the arcuate nucleus of …
Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2
…, DC Hatton, TJ Phillips, DA Finn, MJ Low… - Nature …, 2000 - nature.com
The actions of corticotropin-releasing hormone (Crh), a mediator of endocrine 1 and behavioural
responses to stress 2, and the related hormone urocortin 3 (Ucn) are coordinated by …
responses to stress 2, and the related hormone urocortin 3 (Ucn) are coordinated by …
[HTML][HTML] Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine
The human dopamine D4 receptor (D4R) has received considerable attention because of its
high affinity for the atypical antipsychotic clozapine and the unusually polymorphic nature of …
high affinity for the atypical antipsychotic clozapine and the unusually polymorphic nature of …
Activation of central melanocortin pathways by fenfluramine
D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective
weight loss drugs, but was withdrawn from clinical use because of reports of cardiac …
weight loss drugs, but was withdrawn from clinical use because of reports of cardiac …