Arousal is believed to be needed for upper airway opening in obstructive hypopneas–apneas,
without compelling evidence to support this notion. The association may be incidental. I …

The relation between Inspiratory effort and ventilatory return (flow and volume) is usually
abnormal in patients who reqUireventilatory support because of respiratory distress. Although …

The ventilator's response to the patient's effort is quite different in proportional assist
ventilation (PAV) and pressure support ventilation (PSV). We wished to determine whether this …

The role of chemical control instability in the pathogenesis of obstructive sleep apnea (OSA)
is not clear. We studied 32 patients with OSA during sleep while their upper airway was …

Historically, brief awakenings from sleep (cortical arousals) have been assumed to be vitally
important in restoring airflow and blood-gas disturbances at the end of obstructive sleep …

The contributions of pharyngeal mechanical abnormalities, flow demand, and compensatory
effectiveness to obstructive sleep apnea severity were determined in 82 patients. Flow …

Obstructive sleep disorders develop when the normal reduction in pharyngeal dilator activity
at sleep onset occurs in an individual whose pharynx requires a relatively high level of …

Study Objectives: Manual scoring of polysomnograms (PSG) is labor intensive and has
considerable variance between scorers. Automation of scoring could reduce cost and improve …

Objective Sleep loss and sleep disruption are common in critically ill patients and may
adversely affect clinical outcomes. Although polysomnography remains the most accurate and …

The response to chemical stimuli (chemical responsiveness) and the increases in respiratory
drive required for arousal (arousal threshold) and for opening the airway without arousal (…