Members of the neurotrophin family, including nerve growth factor, brain-derived neurotrophic
factor, neurotrophin-3, and neurotrophin-4/5, and other neurotrophic growth factors such …

OBJECTIVE: The purpose of this retrospective study was to evaluate the efficacy of
anatomic thoracoscopic pulmonary segmentectomy performed under the guidance of 3-dimensional …

BACKGROUND Valve areas derived by the Gorlin formula have been observed to vary with
transvalvular volume flow rate. Continuity equation valve areas calculated from Doppler-…

… perfused with cold 0.1 M phosphate buffer, followed by 4% paraformaldehyde dissolved in
0.1 M PB. Brains … We thank M. Janis for assisting with histological analysis and R. Clem, P. …

The biophysical properties of existing optogenetic tools constrain the scale, speed, and
fidelity of precise optogenetic control. Here, we use structure-guided mutagenesis to engineer …

VGF is a neurotrophin-inducible, activity-regulated gene product that is expressed in CNS
and PNS neurons, in which it is processed into peptides and secreted. VGF synthesis is …

Background and Purpose—Some neuronal subpopulations are especially vulnerable to
ischemic injury. In the spinal cord, large motor neurons are vulnerable to ischemia and are …

Aberrant methylation of promoter CpG islands is known to be a major inactivation mechanism
of the tumor suppressor and tumor-related genes. Some published studies suggest a …

Brain-derived neurotrophic factor (BDNF) is a critical effector of depression-like behaviors
and antidepressant responses. Here, we show that VGF (non-acronymic), which is robustly …

Regulated expression and secretion of BDNF, which activates TrkB receptor signaling, is
known to play a critical role in cognition. Identification of additional modulators of cognitive …