User profiles for Lynn A. Raymond

Lynn A Raymond

Professor of Psychiatry, University of British Columbia, Huntington Study Group, Predict-HD
Verified email at exchange.ubc.ca
Cited by 20389

[HTML][HTML] Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

…, S Roy, CL Wellington, BR Leavitt, LA Raymond… - Cell, 2006 - cell.com
Cleavage of huntingtin (htt) has been characterized in vitro, and accumulation of caspase
cleavage fragments represents an early pathological change in brains of Huntington's disease …

[PDF][PDF] Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

…, BR Leavitt, P Brundin, MR Hayden, LA Raymond - Neuron, 2002 - cell.com
Previous work suggests N-methyl-D-aspartate receptor (NMDAR) activation may be involved
in degeneration of medium-sized spiny striatal neurons in Huntington's disease (HD). Here …

[PDF][PDF] Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice

…, RK Graham, MR Hayden, TH Murphy, LA Raymond - Neuron, 2010 - cell.com
N-methyl-D-aspartate receptor (NMDAR) excitotoxicity is implicated in the pathogenesis of
Huntington's disease (HD), a late-onset neurodegenerative disorder. However, NMDARs are …

[PDF][PDF] Extrasynaptic NMDA receptor involvement in central nervous system disorders

MP Parsons, LA Raymond - Neuron, 2014 - cell.com
NMDA receptor (NMDAR)-induced excitotoxicity is thought to contribute to the cell death
associated with certain neurodegenerative diseases, stroke, epilepsy, and traumatic brain injury…

N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease

MMY Fan, LA Raymond - Progress in neurobiology, 2007 - Elsevier
Many lines of evidence support a role for neuronal damage arising as a result of excessive
activation of glutamate receptors by excitatory amino acids in the pathogenesis of Huntington …

Palmitoylation of huntingtin by HIP14is essential for its trafficking and function

…, PC Orban, A Mullard, CM Cowan, LA Raymond… - Nature …, 2006 - nature.com
Post-translational modification by the lipid palmitate is crucial for the correct targeting and
function of many proteins. Here we show that huntingtin (htt) is normally palmitoylated at …

Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function

LA Raymond, VM André, C Cepeda, CM Gladding… - Neuroscience, 2011 - Elsevier
Huntington's disease (HD) is a progressive, fatal neurological condition caused by an expansion
of CAG (glutamine) repeats in the coding region of the Huntington gene. To date, there …

Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

AJ Milnerwood, LA Raymond - Trends in neurosciences, 2010 - cell.com
Investigations of synaptic transmission and plasticity in mouse models of Huntington's
disease (HD) demonstrate neuronal dysfunction long before the onset of classical disease …

Regulation of ligand-gated ion channels by protein phosphorylation

SL Swope, SJ Moss, LA Raymond… - Advances in second …, 1999 - books.google.com
Neurotransmitter receptors transduce presynaptic information into a postsynaptic response
via the binding of a chemical messenger. One class of receptors includes the ligand-gated …

Subtype-dependence of NMDA receptor channel open probability

N Chen, T Luo, LA Raymond - Journal of Neuroscience, 1999 - Soc Neuroscience
NMDA receptor-mediated calcium transients play a critical role in synaptogenesis, synaptic
plasticity, and excitotoxicity. NMDA receptors are heteromeric complexes of NR1A combined …