User profiles for Lynn A. Raymond
Lynn A RaymondProfessor of Psychiatry, University of British Columbia, Huntington Study Group, Predict-HD Verified email at exchange.ubc.ca Cited by 20389 |
[HTML][HTML] Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
…, S Roy, CL Wellington, BR Leavitt, LA Raymond… - Cell, 2006 - cell.com
Cleavage of huntingtin (htt) has been characterized in vitro, and accumulation of caspase
cleavage fragments represents an early pathological change in brains of Huntington's disease …
cleavage fragments represents an early pathological change in brains of Huntington's disease …
[PDF][PDF] Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease
Previous work suggests N-methyl-D-aspartate receptor (NMDAR) activation may be involved
in degeneration of medium-sized spiny striatal neurons in Huntington's disease (HD). Here …
in degeneration of medium-sized spiny striatal neurons in Huntington's disease (HD). Here …
[PDF][PDF] Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice
N-methyl-D-aspartate receptor (NMDAR) excitotoxicity is implicated in the pathogenesis of
Huntington's disease (HD), a late-onset neurodegenerative disorder. However, NMDARs are …
Huntington's disease (HD), a late-onset neurodegenerative disorder. However, NMDARs are …
[PDF][PDF] Extrasynaptic NMDA receptor involvement in central nervous system disorders
MP Parsons, LA Raymond - Neuron, 2014 - cell.com
NMDA receptor (NMDAR)-induced excitotoxicity is thought to contribute to the cell death
associated with certain neurodegenerative diseases, stroke, epilepsy, and traumatic brain injury…
associated with certain neurodegenerative diseases, stroke, epilepsy, and traumatic brain injury…
N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease
MMY Fan, LA Raymond - Progress in neurobiology, 2007 - Elsevier
Many lines of evidence support a role for neuronal damage arising as a result of excessive
activation of glutamate receptors by excitatory amino acids in the pathogenesis of Huntington …
activation of glutamate receptors by excitatory amino acids in the pathogenesis of Huntington …
Palmitoylation of huntingtin by HIP14is essential for its trafficking and function
…, PC Orban, A Mullard, CM Cowan, LA Raymond… - Nature …, 2006 - nature.com
Post-translational modification by the lipid palmitate is crucial for the correct targeting and
function of many proteins. Here we show that huntingtin (htt) is normally palmitoylated at …
function of many proteins. Here we show that huntingtin (htt) is normally palmitoylated at …
Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function
LA Raymond, VM André, C Cepeda, CM Gladding… - Neuroscience, 2011 - Elsevier
Huntington's disease (HD) is a progressive, fatal neurological condition caused by an expansion
of CAG (glutamine) repeats in the coding region of the Huntington gene. To date, there …
of CAG (glutamine) repeats in the coding region of the Huntington gene. To date, there …
Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease
AJ Milnerwood, LA Raymond - Trends in neurosciences, 2010 - cell.com
Investigations of synaptic transmission and plasticity in mouse models of Huntington's
disease (HD) demonstrate neuronal dysfunction long before the onset of classical disease …
disease (HD) demonstrate neuronal dysfunction long before the onset of classical disease …
Regulation of ligand-gated ion channels by protein phosphorylation
SL Swope, SJ Moss, LA Raymond… - Advances in second …, 1999 - books.google.com
Neurotransmitter receptors transduce presynaptic information into a postsynaptic response
via the binding of a chemical messenger. One class of receptors includes the ligand-gated …
via the binding of a chemical messenger. One class of receptors includes the ligand-gated …
Subtype-dependence of NMDA receptor channel open probability
N Chen, T Luo, LA Raymond - Journal of Neuroscience, 1999 - Soc Neuroscience
NMDA receptor-mediated calcium transients play a critical role in synaptogenesis, synaptic
plasticity, and excitotoxicity. NMDA receptors are heteromeric complexes of NR1A combined …
plasticity, and excitotoxicity. NMDA receptors are heteromeric complexes of NR1A combined …