The growth hormone receptor (GHR) is expressed in brain regions that are known to participate
in the regulation of energy homeostasis and glucose metabolism. We generated a novel …

Evidence for hypothalamic regulation of energy homeostasis and thermoregulation in brown
adipose tissue (BAT) during aging has been well recognized, yet the central molecular …

Nitric oxide (NO) negatively modulates the secretion of vasopressin (AVP), oxytocin ( OT )
and atrial natriuretic peptide ( ANP ) induced by the increase in extracellular osmolality, …

Leptin is a permissive factor for puberty initiation, participating as a metabolic cue in the
activation of the kisspeptin (Kiss1)-gonadotropin-releasing hormone neuronal circuitry; however, …

Chronic exposure to 4-vinylcycloxene diepoxide (VCD) in rodents accelerates the natural
process of ovarian follicular atresia modelling perimenopause in women. We investigated why …

Branched-chain amino acid (BCAAs: leucine, isoleucine, and valine) contribute to the
development of obesity-associated insulin resistance in the context of consumption of a high-fat …

Many aspects of physiological functions are controlled by the hypothalamus, a brain region
that connects the neuroendocrine system to whole-body metabolism. Growth hormone (GH) …

This work describes the studies on the direct C3-glycosylation of the C19-hydroxylated
cardiotonic steroids strophanthidol, anhydro-ouabagenin, and ouabagenin using a strategy …

Abstract Changes to neonatal nutrition result in long-lasting impairments in energy balance,
which may be described as metabolic programing. Astrocytes, which are interconnected by …

The aim of the present study was to determine whether the TRPV1 channel is involved in
the onset of sodium appetite. For this purpose, we used TRPV1-knockout mice to investigate …