[HTML][HTML] The hallmarks of aging

C López-Otín, MA Blasco, L Partridge, M Serrano… - Cell, 2013 - cell.com
Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

[PDF][PDF] Promoting health and longevity through diet: from model organisms to humans

L Fontana, L Partridge - Cell, 2015 - cell.com
Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated
diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings …

Extending healthy life span—from yeast to humans

L Fontana, L Partridge, VD Longo - science, 2010 - science.org
When the food intake of organisms such as yeast and rodents is reduced (dietary restriction),
they live longer than organisms fed a normal diet. A similar effect is seen when the activity …

[HTML][HTML] Autophagy in healthy aging and disease

…, N Tavernarakis, DC Rubinsztein, L Partridge… - Nature aging, 2021 - nature.com
Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Optimally, mutation and the evolution of ageing

L Partridge, NH Barton - Nature, 1993 - nature.com
Evolutionary explanations of ageing fall into two classes. Organisms might have evolved the
optimal life history, in which survival and fertility late in life are sacrificed for the sake of early …

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

…, O Hendrich, P Fratta, EMC Fisher, L Partridge… - Science, 2014 - science.org
An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal
dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is …

Facing up to the global challenges of ageing

L Partridge, J Deelen, PE Slagboom - Nature, 2018 - nature.com
Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population. …

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

…, H Stocker, E Hafen, SJ Leevers, L Partridge - Science, 2001 - science.org
The Drosophila melanogaster gene chicoencodes an insulin receptor substrate that
functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode …

The ecological context of life history evolution

L Partridge, PH Harvey - Science, 1988 - science.org
There is now a good theoretical understanding of life history evolution, and detailed explicit
optimality models have been constructed. These present a challenge for empirical work …

[PDF][PDF] Hallmarks of aging: An expanding universe

C López-Otín, MA Blasco, L Partridge, M Serrano… - Cell, 2023 - cell.com
Aging is driven by hallmarks fulfilling the following three premises: (1) their age-associated
manifestation, (2) the acceleration of aging by experimentally accentuating them, and (3) the …