The lung microbiome regulates brain autoimmunity

L Hosang, RC Canals, FJ van der Flier, J Hollensteiner… - Nature, 2022 - nature.com
Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated autoimmune
disease of the central nervous system 1 . In addition, the lung serves as a niche for the …

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

SA Berghoff, L Spieth, T Sun, L Hosang… - Nature …, 2021 - nature.com
The repair of inflamed, demyelinated lesions as in multiple sclerosis (MS) necessitates the
clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a …

[HTML][HTML] Dietary cholesterol promotes repair of demyelinated lesions in the adult brain

…, J Winchenbach, SK Stumpf, L Hosang… - Nature …, 2017 - nature.com
Multiple Sclerosis (MS) is an inflammatory demyelinating disorder in which remyelination
failure contributes to persistent disability. Cholesterol is rate-limiting for myelin biogenesis in …

Progressive maturation of silent synapses governs the duration of a critical period

…, MH Wong, C Wenzel, L Hosang… - Proceedings of the …, 2015 - National Acad Sciences
During critical periods, all cortical neural circuits are refined to optimize their functional
properties. The prevailing notion is that the balance between excitation and inhibition determines …

[PDF][PDF] Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice

SA Berghoff, L Spieth, T Sun, L Hosang, C Depp… - Cell Reports, 2021 - cell.com
Astrocyte-derived cholesterol supports brain cells under physiological conditions. However,
in demyelinating lesions, astrocytes downregulate cholesterol synthesis, and the cholesterol …

Ketogenic diet uncovers differential metabolic plasticity of brain cells

…, M Mitkovski, N Kannaiyan, L Hosang… - Science …, 2022 - science.org
To maintain homeostasis, the body, including the brain, reprograms its metabolism in response
to altered nutrition or disease. However, the consequences of these challenges for the …

[HTML][HTML] An opposing function of paralogs in balancing developmental synapse maturation

PD Favaro, X Huang, L Hosang, S Stodieck, L Cui… - PLoS …, 2018 - journals.plos.org
The disc-large (DLG)–membrane-associated guanylate kinase (MAGUK) family of proteins
forms a central signaling hub of the glutamate receptor complex. Among this family, some …

2-Methoxyestradiol-3, 17-O, O-bis-sulfamate inhibits store-operated Ca2+ entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis

L Hosang, A Löhndorf, W Dohle, A Rosche… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Ca 2+ signaling is one of the essential signaling systems for T lymphocyte activation, the
latter being an essential step in the pathogenesis of autoimmune diseases such as multiple …

Long-term visual training increases visual acuity and long-term monocular deprivation promotes ocular dominance plasticity in adult standard cage-raised mice

L Hosang, R Yusifov, S Löwel - Eneuro, 2018 - eneuro.org
For routine behavioral tasks, mice predominantly rely on olfactory cues and tactile information.
In contrast, their visual capabilities appear rather restricted, raising the question whether …

[HTML][HTML] 2-Methoxyestradiol and its derivatives inhibit store-operated Ca2+ entry in T cells: Identification of a new and potent inhibitor

A Löhndorf, L Hosang, W Dohle, F Odoardi… - … et Biophysica Acta (BBA …, 2021 - Elsevier
T cell activation starts with formation of second messengers that release Ca 2+ from the
endoplasmic reticulum (ER) and thereby activate store-operated Ca 2+ entry (SOCE), one of the …