Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics
Optogenetics has revolutionized the experimental interrogation of neural circuits and holds
promise for the treatment of neurological disorders. It is limited, however, because visible …
promise for the treatment of neurological disorders. It is limited, however, because visible …
Geometry and the organizational principle of spine synapses along a dendrite
LK Parajuli, H Urakubo, A Takahashi-Nakazato… - eneuro, 2020 - eneuro.org
Precise information on synapse organization in a dendrite is crucial to understanding the
mechanisms underlying voltage integration and the variability in the strength of synaptic inputs …
mechanisms underlying voltage integration and the variability in the strength of synaptic inputs …
[HTML][HTML] Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons
WC Oh, LK Parajuli, K Zito - Cell reports, 2015 - cell.com
Competition between synapses contributes to activity-dependent refinement of the nervous
system during development. Does local competition between neighboring synapses drive …
system during development. Does local competition between neighboring synapses drive …
α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model
T Taguchi, M Ikuno, M Hondo, LK Parajuli, K Taguchi… - Brain, 2020 - academic.oup.com
Parkinson’s disease is one of the most common movement disorders and is characterized
by dopaminergic cell loss and the accumulation of pathological α-synuclein, but its precise …
by dopaminergic cell loss and the accumulation of pathological α-synuclein, but its precise …
Quantitative regional and ultrastructural localization of the Cav2. 3 subunit of R-type calcium channel in mouse brain
LK Parajuli, C Nakajima, A Kulik, K Matsui… - Journal of …, 2012 - Soc Neuroscience
R-type calcium channels (RTCCs) are well known for their role in synaptic plasticity, but little
is known about their subcellular distribution across various neuronal compartments. Using …
is known about their subcellular distribution across various neuronal compartments. Using …
Distinct cell-and layer-specific expression patterns and independent regulation of Kv2 channel subtypes in cortical pyramidal neurons
…, D Guan, E Bocksteins, LK Parajuli… - Journal of …, 2015 - Soc Neuroscience
The Kv2 family of voltage-gated potassium channel α subunits, comprising Kv2.1 and Kv2.2,
mediate the bulk of the neuronal delayed rectifier K + current in many mammalian central …
mediate the bulk of the neuronal delayed rectifier K + current in many mammalian central …
Cell type–specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptors
D Mandikian, E Bocksteins, LK Parajuli… - Journal of …, 2014 - Wiley Online Library
The Kv2.1 voltage‐gated K + channel is widely expressed throughout mammalian brain,
where it contributes to dynamic activity‐dependent regulation of intrinsic neuronal excitability. …
where it contributes to dynamic activity‐dependent regulation of intrinsic neuronal excitability. …
GBA haploinsufficiency accelerates alpha-synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson's disease
…, H Yamakado, H Akiyama, LK Parajuli… - Human molecular …, 2019 - academic.oup.com
Parkinson’s disease (PD) is characterized by dopaminergic (DA) cell loss and the accumulation
of pathological alpha synuclein (asyn), but its precise pathomechanism remains unclear, …
of pathological alpha synuclein (asyn), but its precise pathomechanism remains unclear, …
[HTML][HTML] Three-dimensional structure of dendritic spines revealed by volume electron microscopy techniques
LK Parajuli, M Koike - Frontiers in Neuroanatomy, 2021 - frontiersin.org
Electron microscopy (EM)-based synaptology is a fundamental discipline for achieving a
complex wiring diagram of the brain. A quantitative understanding of synaptic ultrastructure also …
complex wiring diagram of the brain. A quantitative understanding of synaptic ultrastructure also …
Developmental changes in dendritic spine morphology in the striatum and their alteration in an A53T α-synuclein transgenic mouse model of Parkinson's disease
LK Parajuli, K Wako, S Maruo, S Kakuta, T Taguchi… - eneuro, 2020 - eneuro.org
The aging process is accompanied by various neurophysiological changes, and the severity
of neurodegenerative disorders such as Parkinson’s disease (PD) increases with aging. …
of neurodegenerative disorders such as Parkinson’s disease (PD) increases with aging. …