Hypoxic-ischemic and traumatic brain injuries are leading causes of long-term mortality and
disability in infants and children. Although several preclinical models using rodents of …

This review considers the pathobiology of non-impact blast-induced neurotrauma (BINT).
The pathobiology of traumatic brain injury (TBI) has been historically studied in experimental …

Traumatic brain injury (TBI) is the leading cause of morbidity and mortality among children
and both clinical and experimental data reveal that the immature brain is unique in its …

Spinal cord injury produces prominent disruption of the blood‐spinal cord barrier. We have
defined the blood‐spinal cord barrier breakdown to the protein luciferase (61 kDa) in the …

Stroke continues to be a serious and significant health problem in the USA and worldwide.
This article will emphasize the need for good laboratory practices, transparent scientific …

Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in both injury
and repair mechanisms in the CNS. Pharmacological blockade of MMPs, limited to the first …

Blood vessels in the CNS form a specialized and critical structure, the blood–brain barrier (BBB).
We present a resource to understand the molecular mechanisms that regulate BBB …

The immune response that accompanies spinal cord injury contributes to both injury and
reparative processes. It is this duality that is the focus of this review. Here, we consider the …

Clinical and experimental data show that traumatic brain injury (TBI)-induced cognitive changes
are often manifest as deficits in hippocampal-dependent functions of spatial information …

This review will focus on matrix metalloproteinases (MMPs) and their inhibitors in the
context of spinal cord injury (SCI). MMPs have a specific cellular and temporal pattern of …