Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was …

Alzheimer’s disease (AD) is the major cause of dementia, characterized by the presence of
amyloid-beta plaques and neurofibrillary tau tangles. Plaques and tangles are associated …

Abstract Systems neuroscience is still mainly a neuronal field, despite the plethora of evidence
supporting the fact that astrocytes modulate local neural circuits, networks, and complex …

Introduction The cerebrospinal fluid (CSF) biomarkers amyloid-β (Aβ), tau and phosphorylated
tau (p-tau181) are now used for the diagnosis of Alzheimer’s disease (AD). Aβ40 is the …

Calcium homeostasis plays a major role in maintaining neuronal function under physiological
conditions. Amyloid-β (Aβ) initiates pathological processes that include disruption in …

Slow oscillations are important for consolidation of memory during sleep, and Alzheimer’s
disease (AD) patients experience memory disturbances. Thus, we examined slow oscillation …

Glial cells account for between 50% and 90% of all human brain cells, and serve a variety of
important developmental, structural, and metabolic functions. Recent experimental efforts …

Alzheimer’s disease (AD) is characterized by progressive memory loss and cognitive
decline. These impairments correlate with early alterations in neuronal network activity in AD …

Patients with Alzheimer’s disease (AD) exhibit non-rapid eye movement (NREM) sleep
disturbances in addition to memory deficits. Disruption of NREM slow waves occurs early in the …

Neuronal activity patterns are disrupted in neurodegenerative disorders, including Alzheimer’s
disease (AD). One example is disruption of corticothalamic slow oscillations responsible …