Major depressive disorder is a complex disease resulting from aberrant synaptic plasticity
that may be caused by abnormal serotonergic signaling. Using a combination of behavioral, …

It has been suggested that metabotropic glutamate (mGlu) receptor agonists selective for
Group II mGlu receptors may have antipsychotic action. Therefore, we studied whether the …

In the CA1 area of rat hippocampal slices, a combined application of 5-CT, a potent 5-HT 1A
and 5-HT 7 receptor agonist, and WAY 100635, a selective 5-HT 1A receptor antagonist, …

Background and Purpose Because agonists at metabotropic glutamate receptors exert
beneficial effects in schizophrenia, we have assessed the actions of L u AF 21934 and L u AF …

N-methyl-D-aspartate receptor (NMDAR) modulators induce rapid and sustained
antidepressant like-activity in rodents through a molecular mechanism of action that involves the …

To date, neurons have been the primary focus of research on the role of glucocorticoids in
the regulation of brain function and pathological behaviors, such as addiction. Astrocytes, …

Accumulating evidence highlights chemokines as key mediators of the bidirectional crosstalk
between neurons and glial cells aimed at preserving brain functioning. The multifaceted …

In the search for new options for the pharmacological treatment of major depressive disorder,
compounds with a rapid onset of action and high efficacy but lacking a psychotomimetic …

Extended residual persistence of the pesticide dichlorodiphenyltrichloroethane (DDT) raises
concerns about its long-term neurotoxic effects. Little is known, however, about DDT toxicity …

In adult mice, repetitive pairing of stimulation of mystacial vibrissae with an electrical shock
to the tail induces expansion of the cortical representation of stimulated vibrissae …