High concentrations of dexmedetomidine inhibit compound action potentials in frog sciatic nerves without α2 adrenoceptor activation

T Kosugi, K Mizuta, T Fujita… - British journal of …, 2010 - Wiley Online Library
BACKGROUND AND PURPOSE Dexmedetomidine, an α 2 ‐adrenoceptor agonist, exhibits
anti‐nociceptive actions at the spinal cord and enhances the effect of local anaesthetics in …

[PDF][PDF] Distinct mechanisms of over-representation of landmarks and rewards in the hippocampus

M Sato, K Mizuta, T Islam, M Kawano, Y Sekine… - Cell reports, 2020 - cell.com
In the hippocampus, locations associated with salient features are represented by a
disproportionately large number of neurons, but the cellular and molecular mechanisms underlying …

Two functionally distinct serotonergic projections into hippocampus

A Luchetti, A Bota, A Weitemier, K Mizuta… - Journal of …, 2020 - Soc Neuroscience
Hippocampus receives dense serotonergic input specifically from raphe nuclei. However,
what information is carried by this input and its impact on behavior has not been fully …

Modality-specific impairment of hippocampal CA1 neurons of Alzheimer's disease model mice

R Takamura, K Mizuta, Y Sekine, T Islam… - Journal of …, 2021 - Soc Neuroscience
Impairment of episodic memory, a class of memory for spatiotemporal context of an event, is
an early symptom of Alzheimer’s disease. Both spatial and temporal information are …

Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves

H Kawasaki, K Mizuta, T Fujita, E Kumamoto - Life sciences, 2013 - Elsevier
AIMS: Transient receptor potential (TRP) vanilloid-1 (TRPV1) and melastatin-8 (TRPM8)
channels play a role in transmitting sensory information in primary-afferent neurons. TRPV1 …

Hippocampus-dependent goal localization by head-fixed mice in virtual reality

M Sato, M Kawano, K Mizuta, T Islam, MG Lee… - eneuro, 2017 - eneuro.org
The demonstration of the ability of rodents to navigate in virtual reality (VR) has made it an
important behavioral paradigm for studying spatially modulated neuronal activity in these …

Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves

D Tomohiro, K Mizuta, T Fujita, Y Nishikubo… - Life sciences, 2013 - Elsevier
AIMS: Although capsaicin not only activates transient receptor potential vanilloid-1 (TRPV1)
channels but also inhibits nerve conduction, the latter action has not yet been fully examined…

Inhibitory effects of opioids on compound action potentials in frog sciatic nerves and their chemical structures

K Mizuta, T Fujita, T Nakatsuka, E Kumamoto - Life Sciences, 2008 - Elsevier
An opioid tramadol more effectively inhibits compound action potentials (CAPs) than its
metabolite mono-O-demethyl-tramadol (M1). To address further this issue, we examined the …

Multiple coordinated cellular dynamics mediate CA1 map plasticity

K Mizuta, J Nakai, Y Hayashi, M Sato - Hippocampus, 2021 - Wiley Online Library
In the hippocampus, spatial and nonspatial information are jointly represented as a neural
map in which locations associated with salient features are over‐represented by increased …

[HTML][HTML] Opioid actions in primary-afferent fibers—involvement in analgesia and anesthesia

E Kumamoto, K Mizuta, T Fujita - Pharmaceuticals, 2011 - mdpi.com
Opioids inhibit glutamatergic excitatory transmission from the periphery by activating G-protein
coupled opioid receptors in the central terminals of primary-afferent neurons in the spinal …