Many human genes are transcribed from the antisense promoter of L1 retrotransposon
P Nigumann, K Redik, K Mätlik, M Speek - Genomics, 2002 - Elsevier
Human L1 retrotransposon has two transcription-regulatory regions: an internal or sense
promoter driving transcription of the full-length L1, and an antisense promoter (ASP) driving …
promoter driving transcription of the full-length L1, and an antisense promoter (ASP) driving …
L1 antisense promoter drives tissue-specific transcription of human genes
K Mätlik, K Redik, M Speek - BioMed Research International, 2006 - hindawi.com
Transcription of transposable elements interspersed in the genome is controlled by complex
interactions between their regulatory elements and host factors. However, the same …
interactions between their regulatory elements and host factors. However, the same …
[HTML][HTML] PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling
K Kysenius, P Muggalla, K Mätlik, U Arumäe… - Cellular and molecular …, 2012 - Springer
The secreted protease proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density
lipid (LDL) receptor family members LDLR, very low density lipoprotein receptor (…
lipid (LDL) receptor family members LDLR, very low density lipoprotein receptor (…
[HTML][HTML] Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum
K Mätlik, M Baffuto, L Kus, AL Deshmukh, DA Davis… - Nature Genetics, 2024 - nature.com
Brain region-specific degeneration and somatic expansions of the mutant Huntingtin (mHTT)
CAG tract are key features of Huntington’s disease (HD). However, the relationships among …
CAG tract are key features of Huntington’s disease (HD). However, the relationships among …
[HTML][HTML] From microRNA target validation to therapy: lessons learned from studies on BDNF
K Varendi, K Mätlik, JO Andressoo - Cellular and molecular life sciences, 2015 - Springer
During the past decade, the identification of microRNA (miR) targets has become common
laboratory practice, and various strategies are now used to detect interactions between miRs …
laboratory practice, and various strategies are now used to detect interactions between miRs …
Poststroke delivery of MANF promotes functional recovery in rats
K Mätlik, JE Anttila, T Kuan-Yin, OP Smolander… - Science …, 2018 - science.org
Stroke is the most common cause of adult disability in developed countries, largely because
spontaneous recovery is often incomplete, and no pharmacological means to hasten the …
spontaneous recovery is often incomplete, and no pharmacological means to hasten the …
Differential spinal and supraspinal activation of glia in a rat model of morphine tolerance
Abstract Development of tolerance is a well known pharmacological characteristic of opioids
and a major clinical problem. In addition to the known neuronal mechanisms of opioid …
and a major clinical problem. In addition to the known neuronal mechanisms of opioid …
[HTML][HTML] Spared nerve injury causes sexually dimorphic mechanical allodynia and differential gene expression in spinal cords and dorsal root ganglia in rats
FHG Ahlström, K Mätlik, H Viisanen, KJ Blomqvist… - Molecular …, 2021 - Springer
Neuropathic pain is more prevalent in women. However, females are under-represented in
animal experiments, and the mechanisms of sex differences remain inadequately understood…
animal experiments, and the mechanisms of sex differences remain inadequately understood…
Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease
…, E Piccinini, AM Penttinen, K Mätlik… - Neurobiology of …, 2016 - Elsevier
In Parkinson's disease midbrain dopaminergic neurons degenerate and die. Oral medications
and deep brain stimulation can relieve the initial symptoms, but the disease continues to …
and deep brain stimulation can relieve the initial symptoms, but the disease continues to …
Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus
H Autio, K Mätlik, T Rantamäki, L Lindemann… - …, 2011 - Elsevier
Acetylcholinesterase inhibitors are first-line therapies for Alzheimer’s disease. These drugs
increase cholinergic tone in the target areas of the cholinergic neurons of the basal forebrain. …
increase cholinergic tone in the target areas of the cholinergic neurons of the basal forebrain. …