Many human genes are transcribed from the antisense promoter of L1 retrotransposon

P Nigumann, K Redik, K Mätlik, M Speek - Genomics, 2002 - Elsevier
Human L1 retrotransposon has two transcription-regulatory regions: an internal or sense
promoter driving transcription of the full-length L1, and an antisense promoter (ASP) driving …

L1 antisense promoter drives tissue-specific transcription of human genes

K Mätlik, K Redik, M Speek - BioMed Research International, 2006 - hindawi.com
Transcription of transposable elements interspersed in the genome is controlled by complex
interactions between their regulatory elements and host factors. However, the same …

[HTML][HTML] PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling

K Kysenius, P Muggalla, K Mätlik, U Arumäe… - Cellular and molecular …, 2012 - Springer
The secreted protease proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density
lipid (LDL) receptor family members LDLR, very low density lipoprotein receptor (…

[HTML][HTML] Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum

K Mätlik, M Baffuto, L Kus, AL Deshmukh, DA Davis… - Nature Genetics, 2024 - nature.com
Brain region-specific degeneration and somatic expansions of the mutant Huntingtin (mHTT)
CAG tract are key features of Huntington’s disease (HD). However, the relationships among …

[HTML][HTML] From microRNA target validation to therapy: lessons learned from studies on BDNF

K Varendi, K Mätlik, JO Andressoo - Cellular and molecular life sciences, 2015 - Springer
During the past decade, the identification of microRNA (miR) targets has become common
laboratory practice, and various strategies are now used to detect interactions between miRs …

Poststroke delivery of MANF promotes functional recovery in rats

K Mätlik, JE Anttila, T Kuan-Yin, OP Smolander… - Science …, 2018 - science.org
Stroke is the most common cause of adult disability in developed countries, largely because
spontaneous recovery is often incomplete, and no pharmacological means to hasten the …

Differential spinal and supraspinal activation of glia in a rat model of morphine tolerance

…, I Suleymanova, H Tiilikainen, Z Li, TO Lilius, K Mätlik… - Neuroscience, 2018 - Elsevier
Abstract Development of tolerance is a well known pharmacological characteristic of opioids
and a major clinical problem. In addition to the known neuronal mechanisms of opioid …

[HTML][HTML] Spared nerve injury causes sexually dimorphic mechanical allodynia and differential gene expression in spinal cords and dorsal root ganglia in rats

FHG Ahlström, K Mätlik, H Viisanen, KJ Blomqvist… - Molecular …, 2021 - Springer
Neuropathic pain is more prevalent in women. However, females are under-represented in
animal experiments, and the mechanisms of sex differences remain inadequately understood…

Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease

…, E Piccinini, AM Penttinen, K Mätlik… - Neurobiology of …, 2016 - Elsevier
In Parkinson's disease midbrain dopaminergic neurons degenerate and die. Oral medications
and deep brain stimulation can relieve the initial symptoms, but the disease continues to …

Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus

H Autio, K Mätlik, T Rantamäki, L Lindemann… - …, 2011 - Elsevier
Acetylcholinesterase inhibitors are first-line therapies for Alzheimer’s disease. These drugs
increase cholinergic tone in the target areas of the cholinergic neurons of the basal forebrain. …