Optogenetic activation of non-nociceptive Aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats

R Tashima, K Koga, M Sekine, K Kanehisa, Y Kohro… - eneuro, 2018 - eneuro.org
Neuropathic pain is caused by peripheral nerve injury (PNI). One hallmark symptom is allodynia
(pain caused by normally innocuous stimuli), but its mechanistic underpinning remains …

[HTML][HTML] Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch

K Kanehisa, K Koga, S Maejima, Y Shiraishi… - Nature …, 2022 - nature.com
An excitatory neuron subset in the spinal dorsal horn (SDH) that expresses gastrin-releasing
peptide receptors (GRPR) is critical for pruriceptive transmission. Here, we show that …

[HTML][HTML] Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours

K Koga, K Kanehisa, Y Kohro, M Shiratori-Hayashi… - Scientific reports, 2017 - nature.com
Inhibitory interneurons in the spinal dorsal horn (SDH) are crucial for processing somatosensory
information originating in the periphery. However, the effects of the acute and selective …

Specific activation of inhibitory interneurons in the spinal dorsal horn suppresses repetitive scratching in mouse models of chronic itch

K Kanehisa, M Shiratori-Hayashi, K Koga… - Journal of …, 2017 - jdsjournal.com
Chronic itch is a debilitating symptom of inflammatory skin conditions, such as atopic and
contact dermatitis and dry skin, and affects millions of individuals worldwide. There are …

Optogenetic activation of non-nociceptive Aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats

T Ryoichi, K Keisuke, S Misuzu, K Kensho… - 日本薬理学会年会要旨 …, 2018 - cir.nii.ac.jp
Neuropathic pain is caused by peripheral nerve injury (PNI). One hallmark symptom is allodynia
(pain caused by normally innocuous stimuli), but its mechanistic underpinning remains …

Rapid and selective inhibition of dorsal horn inhibitory interneurons induces morphine-resistant spontaneous nocifensive behaviors

K Koga, K Kanehisa, H Tozaki-Saitoh… - … for Annual Meeting of …, 2018 - jstage.jst.go.jp
Somatosensory information from the periphery through primary afferents is properly
processed and integrated by neuronal circuits in the spinal dorsal horn (SDH). Excitatory and …

Targeting Peripheral μ-opioid Receptors or μ-opioid Receptor-Expressing Neurons Does not Prevent Morphine-induced Mechanical Allodynia and Anti-allodynic …

F Du, G Yin, L Han, X Liu, D Dong, K Duan, J Huo… - Neuroscience …, 2023 - Springer
The chronic use of morphine and other opioids is associated with opioid-induced hypersensitivity
(OIH) and analgesic tolerance. Among the different forms of OIH and tolerance, the …

Prenatal expression of purinergic receptor P2X3 in human dorsal root ganglion

A Pan, H Wu, M Li, D Lu, X He, X Yi, XX Yan, Z Li - Purinergic signalling, 2012 - Springer
The dorsal root ganglion (DRG) is consisted of neurons that relay multiple types of spinal
sensory stimuli to the central nervous system. Several neuroactive molecules may be involved …

Efficacy of early superficial temporal artery–middle cerebral artery double anastomoses for atherosclerotic occlusion in patients with progressing stroke

A Inoue, K Kohno, S Iwata, S Ohue, S Ozaki… - Journal of Stroke and …, 2017 - Elsevier
Background We investigated the efficacy of early superficial temporal artery–middle
cerebral artery (STA–MCA) double anastomoses for patients with progressing stroke due to …

[HTML][HTML] Usefulness of cervical computed tomography and magnetic resonance imaging for rapid diagnosis of crowned dens syndrome: A case report and review of …

A Inoue, K Kohno, S Ninomiya, H Tomita… - International Journal of …, 2017 - Elsevier
Introduction Crowned dens syndrome is a rare disease entity which radiologically shows
calcification of the cruciform ligament around the odontoid process. We report a patient with …