Regulation of cell survival by secreted proneurotrophins
R Lee, P Kermani, KK Teng, BL Hempstead - Science, 2001 - science.org
Neurotrophins are growth factors that promote cell survival, differentiation, and cell death.
They are synthesized as proforms that can be cleaved intracellularly to release mature, …
They are synthesized as proforms that can be cleaved intracellularly to release mature, …
Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity
PT Pang, HK Teng, E Zaitsev, NT Woo, K Sakata… - Science, 2004 - science.org
Long-term memory is thought to be mediated by protein synthesis–dependent, late-phase
long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and …
long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and …
ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
HK Teng, KK Teng, R Lee, S Wright… - Journal of …, 2005 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) is best characterized for critical roles in neuronal
survival, differentiation, and synaptic modulation mediated by the TrkB receptor tyrosine …
survival, differentiation, and synaptic modulation mediated by the TrkB receptor tyrosine …
Sortilin is essential for proNGF-induced neuronal cell death
A Nykjaer, R Lee, KK Teng, P Jansen, P Madsen… - Nature, 2004 - nature.com
Sortilin 1 (∼95 kDa) is a member of the recently discovered family of Vps10p-domain receptors
2 , 3 , and is expressed in a variety of tissues, notably brain, spinal cord and muscle. It …
2 , 3 , and is expressed in a variety of tissues, notably brain, spinal cord and muscle. It …
Variant brain-derived neurotrophic factor (BDNF)(Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells …
…, PD Patel, G Sant, CX Meng, KK Teng… - Journal of …, 2004 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) plays a critical role in nervous system and
cardiovascular development and function. Recently, a common single nucleotide polymorphism in …
cardiovascular development and function. Recently, a common single nucleotide polymorphism in …
[HTML][HTML] p21ras as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress (∗)
HM Lander, JS Ogiste, KK Teng… - Journal of Biological …, 1995 - ASBMB
Reactive free radicals have been implicated in mediating signal transduction by a variety of
stimuli. We have investigated the role of p21 ras in mediating free radical signaling. Our …
stimuli. We have investigated the role of p21 ras in mediating free radical signaling. Our …
Understanding proneurotrophin actions: Recent advances and challenges
KK Teng, S Felice, T Kim… - Developmental …, 2010 - Wiley Online Library
Neurotrophins are initially synthesized as larger precursors (proneurotrophins), which
undergo proteolytic cleavage to yield mature forms. Although the functions of the mature …
undergo proteolytic cleavage to yield mature forms. Although the functions of the mature …
A unique pathway for sustained neurotrophin signaling through an ankyrin‐rich membrane‐spanning protein
JC Arévalo, H Yano, KK Teng, MV Chao - The EMBO journal, 2004 - embopress.org
A major question in cell biology is how molecular specificity is achieved by different growth
factor receptors that activate apparently identical signaling events. For the neurotrophin family…
factor receptors that activate apparently identical signaling events. For the neurotrophin family…
Molecular and structural insight into proNGF engagement of p75NTR and sortilin
Nerve growth factor (NGF) is initially synthesized as a precursor, proNGF, that is cleaved to
release its C-terminal mature form. Recent studies suggested that proNGF is not an inactive …
release its C-terminal mature form. Recent studies suggested that proNGF is not an inactive …
Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing
Although mature neurotrophins are well described trophic factors that elicit retrograde survival
signaling, the precursor forms of neurotrophins (ie, proneurotrophins) can function as high-…
signaling, the precursor forms of neurotrophins (ie, proneurotrophins) can function as high-…