User profiles for Katherine R. Brimblecombe

Katherine Brimblecombe

Department of Physiology, Anatomy and Genetics. University of Genetics
Verified email at dpag.ox.ac.uk
Cited by 763

The striosome and matrix compartments of the striatum: a path through the labyrinth from neurochemistry toward function

KR Brimblecombe, SJ Cragg - ACS chemical neuroscience, 2017 - ACS Publications
The striatum is a heterogeneous structure with a diverse range of neuron types and
neuromodulators. Three decades of anatomical and biochemical studies have established that the …

Gating of dopamine transmission by calcium and axonal N‐, Q‐, T‐and L‐type voltage‐gated calcium channels differs between striatal domains

KR Brimblecombe, CJ Gracie, NJ Platt… - The Journal of …, 2015 - Wiley Online Library
Key points The voltage‐gated Ca 2+ channels (VGCCs) that catalyse striatal dopamine
transmission are critical to dopamine function and might prime subpopulations of neurons for …

[HTML][HTML] Selective vulnerability in α-synucleinopathies

J Alegre-Abarrategui, KR Brimblecombe… - Acta …, 2019 - Springer
Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy are
neurodegenerative disorders resulting in progressive motor/cognitive deficits among other …

Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice

…, AK Kaufmann, KR Brimblecombe… - Proceedings of the …, 2015 - National Acad Sciences
Midbrain dopaminergic (mDA) neurons are implicated in cognitive functions, neuropsychiatric
disorders, and pathological conditions; hence understanding genes regulating their …

[HTML][HTML] Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter

…, S Vietti-Michelina, MY Tseu, KR Brimblecombe… - Nature …, 2019 - nature.com
Mesostriatal dopaminergic neurons possess extensively branched axonal arbours. Whether
action potentials are converted to dopamine output in the striatum will be influenced …

Substance P weights striatal dopamine transmission differently within the striosome-matrix axis

KR Brimblecombe, SJ Cragg - Journal of Neuroscience, 2015 - Soc Neuroscience
The mammalian striatum has a topographical organization of input–output connectivity, but
a complex internal, nonlaminar neuronal architecture comprising projection neurons of two …

[HTML][HTML] GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model

BM Roberts, NM Doig, KR Brimblecombe… - Nature …, 2020 - nature.com
Striatal dopamine (DA) is critical for action and learning. Recent data show that DA release
is under tonic inhibition by striatal GABA. Ambient striatal GABA tone on striatal projection …

Targeted activation of cholinergic interneurons accounts for the modulation of dopamine by striatal nicotinic receptors

KR Brimblecombe, S Threlfell, D Dautan, P Kosillo… - eneuro, 2018 - eneuro.org
Striatal dopamine (DA) is a major player in action selection and reinforcement. DA release
is under strong local control by striatal ACh acting at axonal nicotinic ACh receptors (nAChRs) …

[HTML][HTML] Striatal dopamine transporter function is facilitated by converging biology of α-Synuclein and cholesterol

…, A Ewing, SJ Cragg, KR Brimblecombe - Frontiers in Cellular …, 2021 - frontiersin.org
Striatal dopamine transporters (DAT) powerfully regulate dopamine signaling, and can
contribute risk to degeneration in Parkinson’s disease (PD). DATs can interact with the neuronal …

[HTML][HTML] Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum

…, JC Mendoza, KR Brimblecombe… - Brain Structure and …, 2023 - Springer
Oligodendrocyte progenitor cells (OPCs) receive synaptic innervation from glutamatergic and
GABAergic axons and can be dynamically regulated by neural activity, resulting in activity-…