Neurobiological sequelae of witnessing stressful events in adult mice
BACKGROUND: It is well known that exposure to severe stress increases the risk for developing
mood disorders. However, most chronic stress models in rodents involve at least some …
mood disorders. However, most chronic stress models in rodents involve at least some …
Repeated ketamine exposure induces an enduring resilient phenotype in adolescent and adult rats
Background Major depressive disorder afflicts up to 10% of adolescents. However, nearly 50%
of those afflicted are considered nonresponsive to available treatments. Ketamine, a …
of those afflicted are considered nonresponsive to available treatments. Ketamine, a …
Methyl supplementation attenuates cocaine-seeking behaviors and cocaine-induced c-Fos activation in a DNA methylation-dependent manner
Epigenetic mechanisms, such as histone modifications, regulate responsiveness to drugs of
abuse, such as cocaine, but relatively little is known about the regulation of addictive-like …
abuse, such as cocaine, but relatively little is known about the regulation of addictive-like …
Behavioral and biochemical sensitivity to low doses of ketamine: Influence of estrous cycle in C57BL/6 mice
AM Dossat, KN Wright, CE Strong, M Kabbaj - Neuropharmacology, 2018 - Elsevier
Rationale Low-dose ketamine is a rapid-acting antidepressant, to which female rodents are
more sensitive as compared to males. However, the mechanism mediating this sex …
more sensitive as compared to males. However, the mechanism mediating this sex …
Juvenile administration of concomitant methylphenidate and fluoxetine alters behavioral reactivity to reward-and mood-related stimuli and disrupts ventral tegmental …
…, SD Iniguez, LF Alcantara, KN Wright… - Journal of …, 2011 - Soc Neuroscience
There is a rise in the concurrent use of methylphenidate (MPH) and fluoxetine (FLX) in pediatric
populations. However, the long-term neurobiological consequences of combined MPH …
populations. However, the long-term neurobiological consequences of combined MPH …
Fluoxetine exposure during adolescence alters responses to aversive stimuli in adulthood
The mechanisms underlying the enduring neurobiological consequences of antidepressant
exposure during adolescence are poorly understood. Here, we assessed the long-term …
exposure during adolescence are poorly understood. Here, we assessed the long-term …
[PDF][PDF] A neural system that represents the association of odors with rewarded outcomes and promotes behavioral engagement
MA Gadziola, LA Stetzik, KN Wright, AJ Milton… - Cell Reports, 2020 - cell.com
Odors are well known to elicit strong emotional and behavioral responses that become
strengthened throughout learning, yet the specific cellular systems involved in odor learning and …
strengthened throughout learning, yet the specific cellular systems involved in odor learning and …
Prediction of individual differences in fear response by novelty seeking, and disruption of contextual fear memory reconsolidation by ketamine
F Duclot, I Perez-Taboada, KN Wright, M Kabbaj - Neuropharmacology, 2016 - Elsevier
Only a portion of the population exposed to trauma will develop persistent emotional alterations
characteristic of posttraumatic stress disorder (PTSD), which illustrates the necessity for …
characteristic of posttraumatic stress disorder (PTSD), which illustrates the necessity for …
Ventral striatal islands of Calleja neurons control grooming in mice
YF Zhang, L Vargas Cifuentes, KN Wright… - Nature …, 2021 - nature.com
The striatum comprises multiple subdivisions and neural circuits that differentially control
motor output. The islands of Calleja (IC) contain clusters of densely packed granule cells …
motor output. The islands of Calleja (IC) contain clusters of densely packed granule cells …
Sex-and dose-dependent abuse liability of repeated subanesthetic ketamine in rats
KJ Schoepfer, CE Strong, SK Saland, KN Wright… - Physiology & …, 2019 - Elsevier
Rationale Subanesthetic ketamine (KET) elicits rapid, robust, but transient antidepressant
effects. KET's antidepressant actions can be augmented and maintained for a longer duration …
effects. KET's antidepressant actions can be augmented and maintained for a longer duration …