User profiles for Kalpana D. Acharya

Kalpana D Acharya

Senior Research Scientist, Massachusetts General Hospital
Verified email at mgh.harvard.edu
Cited by 442

Daily vaginal microbiota fluctuations associated with natural hormonal cycle, contraceptives, diet, and exercise

SD Song, KD Acharya, JE Zhu, CM Deveney… - MSphere, 2020 - Am Soc Microbiol
The microorganisms of the vaginal tract are critical for vaginal and reproductive health.
However, the regulation of these microorganisms is not well understood. Therefore, we …

[HTML][HTML] Estradiol and high fat diet associate with changes in gut microbiota in female ob/ob mice

KD Acharya, X Gao, EP Bless, J Chen, MJ Tetel - Scientific reports, 2019 - nature.com
Estrogens protect against diet-induced obesity in women and female rodents. For example,
a lack of estrogens in postmenopausal women is associated with an increased risk of weight …

[HTML][HTML] Distinct changes in gut microbiota are associated with estradiol-mediated protection from diet-induced obesity in female mice

KD Acharya, HL Noh, ME Graham, S Suk, RH Friedline… - Metabolites, 2021 - mdpi.com
A decrease in ovarian estrogens in postmenopausal women increases the risk of weight gain,
cardiovascular disease, type 2 diabetes, and chronic inflammation. While it is known that …

[HTML][HTML] Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice

KD Acharya, M Graham, H Raman, AER Parakoyi… - Scientific Reports, 2023 - nature.com
Decreased estrogens during menopause are associated with increased risk of anxiety,
depression, type 2 diabetes and obesity. Similarly, depleting estrogens in rodents by ovariectomy…

Oestradiol and diet modulate energy homeostasis and hypothalamic neurogenesis in the adult female mouse

EP Bless, T Reddy, KD Acharya… - Journal of …, 2014 - Wiley Online Library
Leptin and oestradiol have overlapping functions in energy homeostasis and fertility, and
receptors for these hormones are localised in the same hypothalamic regions. Although, …

[HTML][HTML] Differential effects of Akkermansia-enriched fecal microbiota transplant on energy balance in female mice on high-fat diet

KD Acharya, RH Friedline, DV Ward… - Frontiers in …, 2022 - frontiersin.org
Estrogens protect against weight gain and metabolic disruption in women and female
rodents. Aberrations in the gut microbiota composition are linked to obesity and metabolic …

Characterization of the G‐protein‐coupled membrane‐bound estrogen receptor GPR30 in the zebra finch brain reveals a sex difference in gene and protein …

KD Acharya, SL Veney - Developmental neurobiology, 2012 - Wiley Online Library
Estradiol‐induced structural dimorphisms exist in the songbird brain. However, how they
arise is not clear since there is a scarce distribution of ERα and lack of ERβ in song control …

Adult neurogenesis in the female mouse hypothalamus: estradiol and high-fat diet alter the generation of newborn neurons expressing estrogen receptor α

EP Bless, J Yang, KD Acharya, SA Nettles… - eneuro, 2016 - eneuro.org
Estrogens and leptins act in the hypothalamus to maintain reproduction and energy
homeostasis. Neurogenesis in the adult mammalian hypothalamus has been implicated in the …

Nuclear receptor coactivators: regulators of steroid action in brain and behaviour

MJ Tetel, KD Acharya - Journal of neuroendocrinology, 2013 - Wiley Online Library
Steroid hormones act in specific regions of the brain to alter behaviour and physiology.
Although it has been well established that the bioavailability of the steroid and the expression of …

The progestin receptor interactome in the female mouse hypothalamus: Interactions with synaptic proteins are isoform specific and ligand dependent

KD Acharya, SA Nettles, KJ Sellers, DD Im, M Harling… - eneuro, 2017 - eneuro.org
Progestins bind to the progestin receptor (PR) isoforms, PR-A and PR-B, in brain to influence
development, female reproduction, anxiety, and stress. Hormone-activated PRs associate …