Regulation of neocortical interneuron development and the implications for neurodevelopmental disorders

P Levitt, KL Eagleson, EM Powell - Trends in neurosciences, 2004 - cell.com
Neurodevelopmental disorders typically have complex endophenotypes, which can include
abnormalities in neuronal excitability, processing of complex information, as well as …

Social origins of developmental risk for mental and physical illness

JL Cameron, KL Eagleson, NA Fox… - Journal of …, 2017 - Soc Neuroscience
Adversity in early childhood exerts an enduring impact on mental and physical health,
academic achievement, lifetime productivity, and the probability of interfacing with the criminal …

Patterning and specification of the cerebral cortex

P Levitt, MF Barbe, KL Eagleson - Annual review of …, 1997 - annualreviews.org
▪ Abstract Regionalization of the cerebral cortex occurs during development by the formation
of anatomically and functionally discrete areas of the brain. Descriptive evidence based on …

Disruption of Foxg1 expression by knock-in of cre recombinase: effects on the development of the mouse telencephalon

KL Eagleson, LJS McFadyen-Ketchum, ET Ahrens… - Neuroscience, 2007 - Elsevier
The cre/loxP system is used routinely to manipulate gene expression in the mouse nervous
system. In order to delete genes specifically from the telencephalon, the Foxg1-cre line was …

Dynamic gene and protein expression patterns of the autism‐associated met receptor tyrosine kinase in the developing mouse forebrain

…, DB Campbell, KL Eagleson… - Journal of …, 2009 - Wiley Online Library
The establishment of appropriate neural circuitry depends on the coordination of multiple
developmental events across space and time. These events include proliferation, migration, …

Evidence of cell‐nonautonomous changes in dendrite and dendritic spine morphology in the met‐signaling–deficient mouse forebrain

MC Judson, KL Eagleson, L Wang… - Journal of Comparative …, 2010 - Wiley Online Library
Human genetic findings and murine neuroanatomical expression mapping have intersected
to implicate Met receptor tyrosine kinase signaling in the development of forebrain circuits …

The autism risk genes MET and PLAUR differentially impact cortical development

KL Eagleson, DB Campbell, BL Thompson… - Autism …, 2011 - Wiley Online Library
Candidate risk genes for autism spectrum disorder (ASD) have been identified, but the challenge
of determining their contribution to pathogenesis remains. We previously identified two …

The pleiotropic MET receptor network: circuit development and the neural-medical interface of autism

KL Eagleson, Z Xie, P Levitt - Biological psychiatry, 2017 - Elsevier
People with autism spectrum disorder and other neurodevelopmental disorders (NDDs) are
behaviorally and medically heterogeneous. The combination of polygenicity and gene …

Region‐ and age‐specific deficits in γ‐aminobutyric acidergic neuron development in the telencephalon of the uPAR–/– mouse

KL Eagleson, A Bonnin… - Journal of Comparative …, 2005 - Wiley Online Library
We have previously shown that in adult mice with a null mutation in the urokinase‐type
plasminogen activator receptor (uPAR) gene, maintained on a C57BL/6J/129Sv background, …

Distinct intracellular signaling mediates C‐MET regulation of dendritic growth and synaptogenesis

KL Eagleson, CJ Lane… - Developmental …, 2016 - Wiley Online Library
Hepatocyte growth factor (HGF) activation of the MET receptor tyrosine kinase influences
multiple neurodevelopmental processes. Evidence from human imaging and mouse models …