[HTML][HTML] Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6
JW Nicholatos, AB Francisco, CA Bender, T Yeh… - Acta neuropathologica …, 2018 - Springer
Parkinson’s disease is characterized by progressive death of dopaminergic neurons, leading
to motor and cognitive dysfunction. Epidemiological studies consistently show that the use …
to motor and cognitive dysfunction. Epidemiological studies consistently show that the use …
The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release
…, DT Tran, E Guilmette, JW Nicholatos… - Proceedings of the …, 2021 - National Acad Sciences
Inositol-1,4,5-triphosphate (IP 3 ) kinase B (ITPKB) is a ubiquitously expressed lipid kinase
that inactivates IP 3 , a secondary messenger that stimulates calcium release from the …
that inactivates IP 3 , a secondary messenger that stimulates calcium release from the …
Cellular energetics and mitochondrial uncoupling in canine aging
JW Nicholatos, TM Robinette, SVP Tata, JD Yordy… - Geroscience, 2019 - Springer
The first domesticated companion animal, the dog, is currently represented by over 190
unique breeds. Across these numerous breeds, dogs have exceptional variation in lifespan (…
unique breeds. Across these numerous breeds, dogs have exceptional variation in lifespan (…
[HTML][HTML] SIRT1 accelerates the progression of activity-based anorexia
TM Robinette, JW Nicholatos, AB Francisco… - Nature …, 2020 - nature.com
Food consumption is fundamental for life, and eating disorders often result in devastating or
life-threatening conditions. Anorexia nervosa (AN) is characterized by a persistent restriction …
life-threatening conditions. Anorexia nervosa (AN) is characterized by a persistent restriction …
[HTML][HTML] Lysophosphatidylcholine acyltransferase 1 promotes pathology and toxicity in two distinct cell-based alpha-synuclein models
JW Nicholatos, D Tran, YT Liu, WD Hirst… - Neuroscience …, 2022 - Elsevier
Alpha-synuclein (αSyn) pathology is a hallmark of Parkinson’s disease. Here we show that
lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a regulator of αSyn pathology and …
lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a regulator of αSyn pathology and …
SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures
JW Nicholatos, J Groot, S Dhokai, D Tran, L Hrdlicka… - Eneuro, 2021 - eneuro.org
Here, we report the independent discovery and validation of stearoyl-CoA desaturase (SCD)
as a modulator of α-synuclein (αSyn)-induced pathology and toxicity in cell-based …
as a modulator of α-synuclein (αSyn)-induced pathology and toxicity in cell-based …
SIRT6 knockout cells resist apoptosis initiation but not progression: a computational method to evaluate the progression of apoptosis
S Domanskyi, JW Nicholatos, JE Schilling, V Privman… - Apoptosis, 2017 - Springer
Apoptosis is essential for numerous processes, such as development, resistance to infections,
and suppression of tumorigenesis. Here, we investigate the influence of the nutrient …
and suppression of tumorigenesis. Here, we investigate the influence of the nutrient …
Intrinsic Mitochondrial Dynamics and Cytoskeletal Properties Underlie Aging Diversity in Dogs
JW Nicholatos, SVP Tata, TM Robinette, AB Francisco… - 2018 - papers.ssrn.com
Among its many breeds, dogs exhibit exceptional variation in their rate of aging and
average lifespan, which presents an opportunity to identify longevity-associated traits via …
average lifespan, which presents an opportunity to identify longevity-associated traits via …
[BOOK][B] Cellular Energetics in the Canine Model of Aging & SIRT6 as a Therapeutic Target for Parkinson's Disease
JW Nicholatos - 2018 - search.proquest.com
PART 1: Dogs display exceptional lifespan variation across their many breeds, presenting
an opportunity to discover longevity-determining traits. We performed a genome-wide …
an opportunity to discover longevity-determining traits. We performed a genome-wide …
Coordinated regulation of protein synthesis and degradation by mTORC1
Y Zhang, J Nicholatos, JR Dreier, SJH Ricoult… - Nature, 2014 - nature.com
Eukaryotic cells coordinately control anabolic and catabolic processes to maintain cell and
tissue homeostasis. Mechanistic target of rapamycin complex 1 (mTORC1) promotes nutrient-…
tissue homeostasis. Mechanistic target of rapamycin complex 1 (mTORC1) promotes nutrient-…