[HTML][HTML] Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6

JW Nicholatos, AB Francisco, CA Bender, T Yeh… - Acta neuropathologica …, 2018 - Springer
Parkinson’s disease is characterized by progressive death of dopaminergic neurons, leading
to motor and cognitive dysfunction. Epidemiological studies consistently show that the use …

The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release

…, DT Tran, E Guilmette, JW Nicholatos… - Proceedings of the …, 2021 - National Acad Sciences
Inositol-1,4,5-triphosphate (IP 3 ) kinase B (ITPKB) is a ubiquitously expressed lipid kinase
that inactivates IP 3 , a secondary messenger that stimulates calcium release from the …

Cellular energetics and mitochondrial uncoupling in canine aging

JW Nicholatos, TM Robinette, SVP Tata, JD Yordy… - Geroscience, 2019 - Springer
The first domesticated companion animal, the dog, is currently represented by over 190
unique breeds. Across these numerous breeds, dogs have exceptional variation in lifespan (…

[HTML][HTML] SIRT1 accelerates the progression of activity-based anorexia

TM Robinette, JW Nicholatos, AB Francisco… - Nature …, 2020 - nature.com
Food consumption is fundamental for life, and eating disorders often result in devastating or
life-threatening conditions. Anorexia nervosa (AN) is characterized by a persistent restriction …

[HTML][HTML] Lysophosphatidylcholine acyltransferase 1 promotes pathology and toxicity in two distinct cell-based alpha-synuclein models

JW Nicholatos, D Tran, YT Liu, WD Hirst… - Neuroscience …, 2022 - Elsevier
Alpha-synuclein (αSyn) pathology is a hallmark of Parkinson’s disease. Here we show that
lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a regulator of αSyn pathology and …

SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures

JW Nicholatos, J Groot, S Dhokai, D Tran, L Hrdlicka… - Eneuro, 2021 - eneuro.org
Here, we report the independent discovery and validation of stearoyl-CoA desaturase (SCD)
as a modulator of α-synuclein (αSyn)-induced pathology and toxicity in cell-based …

SIRT6 knockout cells resist apoptosis initiation but not progression: a computational method to evaluate the progression of apoptosis

S Domanskyi, JW Nicholatos, JE Schilling, V Privman… - Apoptosis, 2017 - Springer
Apoptosis is essential for numerous processes, such as development, resistance to infections,
and suppression of tumorigenesis. Here, we investigate the influence of the nutrient …

Intrinsic Mitochondrial Dynamics and Cytoskeletal Properties Underlie Aging Diversity in Dogs

JW Nicholatos, SVP Tata, TM Robinette, AB Francisco… - 2018 - papers.ssrn.com
Among its many breeds, dogs exhibit exceptional variation in their rate of aging and
average lifespan, which presents an opportunity to identify longevity-associated traits via …

[BOOK][B] Cellular Energetics in the Canine Model of Aging & SIRT6 as a Therapeutic Target for Parkinson's Disease

JW Nicholatos - 2018 - search.proquest.com
PART 1: Dogs display exceptional lifespan variation across their many breeds, presenting
an opportunity to discover longevity-determining traits. We performed a genome-wide …

Coordinated regulation of protein synthesis and degradation by mTORC1

Y Zhang, J Nicholatos, JR Dreier, SJH Ricoult… - Nature, 2014 - nature.com
Eukaryotic cells coordinately control anabolic and catabolic processes to maintain cell and
tissue homeostasis. Mechanistic target of rapamycin complex 1 (mTORC1) promotes nutrient-…