We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD),
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and
sporadic Parkinson's disease (PD). Elevated LRRK2 kinase activity and neurodegeneration are …

Mutations in the catalytic Roc‐COR and kinase domains of leucine‐rich repeat kinase 2 (LRRK2)
are a common cause of familial Parkinson's disease (PD). LRRK2 mutations cause PD …

Mutations in PTEN-induced putative kinase 1 (PINK1) and parkin cause autosomal-recessive
Parkinson's disease through a common pathway involving mitochondrial quality control. …

The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause of familial
Parkinson's disease (PD). This mutation results in dopaminergic neurodegeneration via …

The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) causes familial Parkinson’s
disease (PD) and is also found in a subset of idiopathic cases. Prior studies in Drosophila …

LRRK2 mutations are a frequent cause of familial Parkinson disease (PD) and are also found
in a number of sporadic PD cases. PD-linked G2019S and I2020T mutations in the kinase …

Calcium regulation is a critical process in neurons, and Ca 2+ signaling is a major contributor
to neurological disorders including Parkinson’s disease (PD). Here, combining calcium …

A common cause of Parkinson disease are missense mutations in the leucine‐rich repeat
kinase 2 (LRRK2) catalytic Roc‐COR domain, leading to a decrease in GTPase activity; and …

Human brain transcriptomes can highlight biological pathways associated with Alzheimer’s
disease (AD); however, challenges remain to link expression changes with causal triggers. …