User profiles for Joshua L. Plotkin
Joshua PlotkinStony Brook University Verified email at stonybrook.edu Cited by 2535 |
MicroRNA-128 governs neuronal excitability and motor behavior in mice
The control of motor behavior in animals and humans requires constant adaptation of
neuronal networks to signals of various types and strengths. We found that microRNA-128 (miR-…
neuronal networks to signals of various types and strengths. We found that microRNA-128 (miR-…
[HTML][HTML] Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia
…, SM Graves, LE Sebel, C Alcacer, JL Plotkin… - Nature …, 2014 - nature.com
The striatum is widely viewed as the fulcrum of pathophysiology in Parkinson’s disease (PD)
and L-DOPA-induced dyskinesia (LID). In these disease states, the balance in activity of …
and L-DOPA-induced dyskinesia (LID). In these disease states, the balance in activity of …
Differential excitability and modulation of striatal medium spiny neuron dendrites
M Day, D Wokosin, JL Plotkin, X Tian… - Journal of …, 2008 - Soc Neuroscience
The loss of striatal dopamine (DA) in Parkinson's disease (PD) models triggers a cell-type-specific
reduction in the density of dendritic spines in D 2 receptor-expressing striatopallidal …
reduction in the density of dendritic spines in D 2 receptor-expressing striatopallidal …
[PDF][PDF] Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. The
debilitating choreic movements that plague HD patients have been attributed to striatal …
debilitating choreic movements that plague HD patients have been attributed to striatal …
[PDF][PDF] M4 muscarinic receptor signaling ameliorates striatal plasticity deficits in models of L-DOPA-induced dyskinesia
A balanced interaction between dopaminergic and cholinergic signaling in the striatum is
critical to goal-directed behavior. But how this interaction modulates corticostriatal synaptic …
critical to goal-directed behavior. But how this interaction modulates corticostriatal synaptic …
Synaptically driven state transitions in distal dendrites of striatal spiny neurons
JL Plotkin, M Day, DJ Surmeier - Nature neuroscience, 2011 - nature.com
Striatal spiny neurons (SPNs) associate a diverse array of cortically processed information to
regulate action selection. But how this is done by SPNs is poorly understood. A key step in …
regulate action selection. But how this is done by SPNs is poorly understood. A key step in …
Corticostriatal synaptic adaptations in Huntington's disease
JL Plotkin, DJ Surmeier - Current opinion in neurobiology, 2015 - Elsevier
… Author links open overlay panel Joshua L Plotkin , D James Surmeier … Cepeda, L. Galvan,
SM Holley, SP Rao, VM Andre, EP Botelho, JY Chen, JB Watson, K. Deisseroth, MS Levine …
SM Holley, SP Rao, VM Andre, EP Botelho, JY Chen, JB Watson, K. Deisseroth, MS Levine …
The role of dopamine in modulating the structure and function of striatal circuits
…, M Day, T Gertler, S Chan, X Tian, JL Plotkin - Progress in brain …, 2010 - Elsevier
Dopamine (DA) is a key regulator of action selection and associative learning. The striatum
has long been thought to be a major locus of DA action in this process. Although all striatal …
has long been thought to be a major locus of DA action in this process. Although all striatal …
Improving transparency and scientific rigor in academic publishing
EM Prager, KE Chambers, JL Plotkin… - Journal of …, 2019 - Wiley Online Library
Progress in basic and clinical research is slowed when researchers fail to provide a complete
and accurate report of how a study was designed, executed, and the results analyzed. …
and accurate report of how a study was designed, executed, and the results analyzed. …
Compartmental function and modulation of the striatum
EM Prager, JL Plotkin - Journal of neuroscience research, 2019 - Wiley Online Library
The striatum plays a central role in guiding numerous complex behaviors, ranging from motor
control to action selection and reward learning. The diverse responsibilities of the striatum …
control to action selection and reward learning. The diverse responsibilities of the striatum …