User profiles for Joshua L. Plotkin

Joshua Plotkin

Stony Brook University
Verified email at stonybrook.edu
Cited by 2535

MicroRNA-128 governs neuronal excitability and motor behavior in mice

CL Tan, JL Plotkin, MT Venø, M Von Schimmelmann… - Science, 2013 - science.org
The control of motor behavior in animals and humans requires constant adaptation of
neuronal networks to signals of various types and strengths. We found that microRNA-128 (miR-…

[HTML][HTML] Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia

…, SM Graves, LE Sebel, C Alcacer, JL Plotkin… - Nature …, 2014 - nature.com
The striatum is widely viewed as the fulcrum of pathophysiology in Parkinson’s disease (PD)
and L-DOPA-induced dyskinesia (LID). In these disease states, the balance in activity of …

Differential excitability and modulation of striatal medium spiny neuron dendrites

M Day, D Wokosin, JL Plotkin, X Tian… - Journal of …, 2008 - Soc Neuroscience
The loss of striatal dopamine (DA) in Parkinson's disease (PD) models triggers a cell-type-specific
reduction in the density of dendritic spines in D 2 receptor-expressing striatopallidal …

[PDF][PDF] Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease

JL Plotkin, M Day, JD Peterson, Z Xie, GJ Kress… - Neuron, 2014 - cell.com
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. The
debilitating choreic movements that plague HD patients have been attributed to striatal …

[PDF][PDF] M4 muscarinic receptor signaling ameliorates striatal plasticity deficits in models of L-DOPA-induced dyskinesia

W Shen, JL Plotkin, V Francardo, WKD Ko, Z Xie, Q Li… - Neuron, 2015 - cell.com
A balanced interaction between dopaminergic and cholinergic signaling in the striatum is
critical to goal-directed behavior. But how this interaction modulates corticostriatal synaptic …

Synaptically driven state transitions in distal dendrites of striatal spiny neurons

JL Plotkin, M Day, DJ Surmeier - Nature neuroscience, 2011 - nature.com
Striatal spiny neurons (SPNs) associate a diverse array of cortically processed information to
regulate action selection. But how this is done by SPNs is poorly understood. A key step in …

Corticostriatal synaptic adaptations in Huntington's disease

JL Plotkin, DJ Surmeier - Current opinion in neurobiology, 2015 - Elsevier
… Author links open overlay panel Joshua L Plotkin , D James Surmeier … Cepeda, L. Galvan,
SM Holley, SP Rao, VM Andre, EP Botelho, JY Chen, JB Watson, K. Deisseroth, MS Levine …

The role of dopamine in modulating the structure and function of striatal circuits

…, M Day, T Gertler, S Chan, X Tian, JL Plotkin - Progress in brain …, 2010 - Elsevier
Dopamine (DA) is a key regulator of action selection and associative learning. The striatum
has long been thought to be a major locus of DA action in this process. Although all striatal …

Improving transparency and scientific rigor in academic publishing

EM Prager, KE Chambers, JL Plotkin… - Journal of …, 2019 - Wiley Online Library
Progress in basic and clinical research is slowed when researchers fail to provide a complete
and accurate report of how a study was designed, executed, and the results analyzed. …

Compartmental function and modulation of the striatum

EM Prager, JL Plotkin - Journal of neuroscience research, 2019 - Wiley Online Library
The striatum plays a central role in guiding numerous complex behaviors, ranging from motor
control to action selection and reward learning. The diverse responsibilities of the striatum …