User profiles for John D. Houle

John D Houle

Professor of Anatomy and Neurobiology, Drexel University
Verified email at drexelmed.edu
Cited by 3847

Combining an autologous peripheral nervous system “bridge” and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection …

JD Houle, VJ Tom, D Mayes, G Wagoner… - Journal of …, 2006 - Soc Neuroscience
Chondroitinase-ABC (ChABC) was applied to a cervical level 5 (C5) dorsal quadrant
aspiration cavity of the adult rat spinal cord to degrade the local accumulation of inhibitory …

Treatment of the chronically injured spinal cord with neurotrophic factors can promote axonal regeneration from supraspinal neurons

JH Ye, JD Houle - Experimental neurology, 1997 - Elsevier
Axonal regeneration has been demonstrated by supraspinal neurons long after a spinal
cord injury, although this potential seems limited to a few neurons in specific nuclear groups. …

Activated macrophage/microglial cells can promote the regeneration of sensory axons into the injured spinal cord

CMF Prewitt, IR Niesman, CJM Kane, JD Houlé - Experimental neurology, 1997 - Elsevier
A prominent role for phagocytic cells in the regenerative response to CNS or PNS injury has
been suggested by numerous studies. In the present work we tested whether increasing the …

Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury

Y Jin, I Fischer, A Tessler, JD Houle - Experimental neurology, 2002 - Elsevier
Transplants of fibroblasts genetically modified to express BDNF (Fb/BDNF) have been
shown to promote regeneration of rubrospinal axons and recovery of forelimb function when …

Activity-dependent increase in neurotrophic factors is associated with an enhanced modulation of spinal reflexes after spinal cord injury

MP Côté, GA Azzam, MA Lemay, V Zhukareva… - Journal of …, 2011 - liebertpub.com
Activity-based therapies such as passive bicycling and step-training on a treadmill contribute
to motor recovery after spinal cord injury (SCI), leading to a greater number of steps …

Repair of chronic spinal cord injury

JD Houle, A Tessler - Experimental neurology, 2003 - Elsevier
Advances in medical and rehabilitative care now allow the 10–12,000 individuals who suffer
spinal cord injuries each year in the United States to lead productive lives of nearly normal …

Combining peripheral nerve grafts and chondroitinase promotes functional axonal regeneration in the chronically injured spinal cord

VJ Tom, HR Sandrow-Feinberg, K Miller… - Journal of …, 2009 - Soc Neuroscience
Because there currently is no treatment for spinal cord injury, most patients are living with
long-standing injuries. Therefore, strategies aimed at promoting restoration of function to the …

Nanofibrous collagen nerve conduits for spinal cord repair

T Liu, JD Houle, J Xu, BP Chan… - Tissue Engineering Part …, 2012 - liebertpub.com
Nerve regeneration in an injured spinal cord is often restricted, contributing to the devastating
outcome of neurologic impairment below the site of injury. Although implantation of tissue-…

Exercise after spinal cord injury as an agent for neuroprotection, regeneration and rehabilitation

HR Sandrow-Feinberg, JD Houlé - Brain research, 2015 - Elsevier
Spinal cord injury (SCI) is a traumatic event from which there is limited recovery of function,
despite the best efforts of many investigators to devise realistic therapeutic treatments. Partly …

Transplantation of fetal spinal cord tissue into the chronically injured adult rat spinal cord

JD Houlé, PJ Reier - Journal of Comparative Neurology, 1988 - Wiley Online Library
Transplants of fetal central nervous system (CNS) tissue into the acutely injured rat spinal
cord have been demonstrated to differentiate and partially integrate with the adjacent host …