User profiles for Jochen Klucken

Jochen Klucken

University of Luxembourg, Luxembourg Institute of Health, Centre Hospitalier du …
Verified email at uni.lu
Cited by 27213

Technology in Parkinson's disease: challenges and opportunities

…, W Maetzler, JM Dean, J Klucken… - Movement …, 2016 - Wiley Online Library
The miniaturization, sophistication, proliferation, and accessibility of technologies are enabling
the capture of more and previously inaccessible phenomena in Parkinson's disease (PD). …

An emerging era in the management of Parkinson's disease: wearable technologies and the internet of things

…, H Gassner, J Winkler, J Klucken… - IEEE journal of …, 2015 - ieeexplore.ieee.org
Current challenges demand a profound restructuration of the global healthcare system. A
more efficient system is required to cope with the growing world population and increased life …

Inertial sensor-based stride parameter calculation from gait sequences in geriatric patients

…, S Schülein, KG Gaßmann, J Klucken… - IEEE transactions on …, 2014 - ieeexplore.ieee.org
A detailed and quantitative gait analysis can provide evidence of various gait impairments
in elderly people. To provide an objective decision-making basis for gait analysis, simple …

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

M Bodzioch, E Orsó, J Klucken, T Langmann… - Nature …, 1999 - nature.com
Tangier disease (TD) is an autosomal recessive disorder of lipid metabolism 1. It is
characterized by absence of plasma high-density lipoprotein (HDL) and deposition of cholesteryl …

Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro‐and antiinflammatory stimuli

…, E Orsó, T Langmann, J Klucken… - Journal of leukocyte …, 2000 - Wiley Online Library
CD163, also referred to as M130, a member of the scavenger receptor cysteine‐rich family (SRCR)
is exclusively expressed on cells of the monocyte lineage. In freshly isolated …

ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport

J Klucken, C Büchler, E Orso… - Proceedings of the …, 2000 - National Acad Sciences
Excessive uptake of atherogenic lipoproteins such as modified low-density lipoprotein complexes
by vascular macrophages leads to foam cell formation, a critical step in atherogenesis. …

[HTML][HTML] Hsp70 reduces α-synuclein aggregation and toxicity

J Klucken, Y Shin, E Masliah, BT Hyman… - Journal of Biological …, 2004 - ASBMB
Aggregation and cytotoxicity of misfolded α-synuclein is postulated to be crucial in the
disease process of neurodegenerative disorders such as Parkinson's disease and DLB (dementia …

Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages

T Langmann, J Klucken, M Reil, G Liebisch… - Biochemical and …, 1999 - Elsevier
We have cloned the full-length cDNA for the human ATP binding cassette transporter 1 (hABC1).
The 6603-bp open reading frame encodes a polypeptide of 2201 amino acids resulting …

[HTML][HTML] The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates α-synuclein degradation decisions between proteasomal and lysosomal …

Y Shin, J Klucken, C Patterson, BT Hyman… - Journal of Biological …, 2005 - ASBMB
α-Synuclein is a major component of Lewy bodies, the pathological hallmark of Parkinson
disease, dementia with Lewy bodies, and related disorders. Misfolding and aggregation of α-…

[HTML][HTML] Wearable sensors objectively measure gait parameters in Parkinson's disease

…, K Aminian, BM Eskofier, J Winkler, J Klucken - PloS one, 2017 - journals.plos.org
Jochen Klucken reports personal fees outside the submitted … Jochen Klucken reports personal
fees outside the submitted … , Jürgen Winkler, and Jochen Klucken have a patent related to …