Association between immune checkpoint inhibitors with cardiovascular events and atherosclerotic plaque
Background: Immune checkpoint inhibitors (ICIs) treat an expanding range of cancers.
Consistent basic data suggest that these same checkpoints are critical negative regulators of …
Consistent basic data suggest that these same checkpoints are critical negative regulators of …
[HTML][HTML] Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice
SY Toh, J Gong, G Du, JZ Li, S Yang, J Ye, H Yao… - PloS one, 2008 - journals.plos.org
Fsp27, a member of the Cide family proteins, was shown to localize to lipid droplet and
promote lipid storage in adipocytes. We aimed to understand the biological role of Fsp27 in …
promote lipid storage in adipocytes. We aimed to understand the biological role of Fsp27 in …
Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites
Lipid droplets (LDs) are dynamic cellular organelles that control many biological processes.
However, molecular components determining LD growth are poorly understood. Genetic …
However, molecular components determining LD growth are poorly understood. Genetic …
[HTML][HTML] Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes
Mature white adipocytes contain a characteristic unilocular lipid droplet. However, the
molecular mechanisms underlying unilocular lipid droplet formation are poorly understood. We …
molecular mechanisms underlying unilocular lipid droplet formation are poorly understood. We …
Inducible and multiplex gene regulation using CRISPR–Cpf1-based transcription factors
Targeted and inducible regulation of mammalian gene expression is a broadly important
capability. We engineered drug-inducible catalytically inactive Cpf1 nuclease fused to …
capability. We engineered drug-inducible catalytically inactive Cpf1 nuclease fused to …
CIDE proteins and metabolic disorders
J Gong, Z Sun, P Li - Current opinion in lipidology, 2009 - journals.lww.com
CIDE proteins are important regulators of energy homeostasis and are closely linked to the
development of metabolic disorders including obesity, diabetes, and liver steatosis. They …
development of metabolic disorders including obesity, diabetes, and liver steatosis. They …
Downregulation of AMP‐activated protein kinase by Cidea‐mediated ubiquitination and degradation in brown adipose tissue
We previously showed that Cidea −/− mice are resistant to diet‐induced obesity through the
upregulation of energy expenditure. The AMP‐activated protein kinase (AMPK), consisting …
upregulation of energy expenditure. The AMP‐activated protein kinase (AMPK), consisting …
[PDF][PDF] Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development
Q Ouyang, SB Lizarraga, M Schmidt, U Yang, J Gong… - Neuron, 2013 - cell.com
Neuronal arborization is regulated by cell-autonomous and nonautonomous mechanisms
including endosomal signaling via BDNF/TrkB. The endosomal Na + /H + exchanger 6 (NHE6) …
including endosomal signaling via BDNF/TrkB. The endosomal Na + /H + exchanger 6 (NHE6) …
Exosomes mediate cell contact–independent ephrin-Eph signaling during axon guidance
The cellular release of membranous vesicles known as extracellular vesicles (EVs) or exosomes
represents a novel mode of intercellular communication. Eph receptor tyrosine kinases …
represents a novel mode of intercellular communication. Eph receptor tyrosine kinases …
Sodium-glucose co-transporter-2 inhibitors and cardiac outcomes among patients treated with anthracyclines
…, T Quinaglia Araujo Costa Silva, A Zafar, J Gong… - Heart Failure, 2022 - jacc.org
Background Sodium-glucose co-transporter-2 (SGLT2) inhibitors improve outcomes among
patients with established heart failure. Despite supportive basic science studies, there are …
patients with established heart failure. Despite supportive basic science studies, there are …