[PDF][PDF] Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity
JA Zhang, A Mortazavi, BA Williams, BJ Wold… - Cell, 2012 - cell.com
T cell development comprises a stepwise process of commitment from a multipotent precursor.
To define molecular mechanisms controlling this progression, we probed five stages …
To define molecular mechanisms controlling this progression, we probed five stages …
Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer
R Hassan, AT Remaley, ML Sampson, J Zhang… - Clinical cancer …, 2006 - AACR
Purpose: To determine whether mesothelin, a cell surface protein highly expressed in
mesothelioma and ovarian cancer, is shed into serum and if so to accurately measure it. …
mesothelioma and ovarian cancer, is shed into serum and if so to accurately measure it. …
[HTML][HTML] A binding domain on mesothelin for CA125/MUC16
O Kaneko, L Gong, J Zhang, JK Hansen… - Journal of biological …, 2009 - ASBMB
Ovarian cancer and malignant mesothelioma frequently express both mesothelin and
CA125 (also known as MUC16) at high levels on the cell surface. The interaction between …
CA125 (also known as MUC16) at high levels on the cell surface. The interaction between …
[HTML][HTML] Massively parallel nanowell-based single-cell gene expression profiling
…, A Mir, H Hubschle, J Guillory, W Yuan, J Zhang… - BMC genomics, 2017 - Springer
Background Technological advances have enabled transcriptome characterization of cell
types at the single-cell level providing new biological insights. New methods that enable …
types at the single-cell level providing new biological insights. New methods that enable …
Antibody humanization by framework shuffling
WF Dall'Acqua, MM Damschroder, J Zhang, RM Woods… - Methods, 2005 - Elsevier
We report here the humanization of a mouse monoclonal antibody (mAb B233) using a new
technique which we call framework shuffling. mAb B233 was raised against the human …
technique which we call framework shuffling. mAb B233 was raised against the human …
Phase 1 study of the antimesothelin immunotoxin SS1P in combination with pemetrexed and cisplatin for front‐line therapy of pleural mesothelioma and correlation of …
BACKGROUND The primary objective of this study was to determine the safety and
maximum tolerated dose (MTD) of the antimesothelin immunotoxin SS1(dsFv)PE38 (SS1P) (a …
maximum tolerated dose (MTD) of the antimesothelin immunotoxin SS1(dsFv)PE38 (SS1P) (a …
[HTML][HTML] Dietary flavonoids from modified apple reduce inflammation markers and modulate gut microbiota in mice
Apples are rich in polyphenols, which provide antioxidant properties, mediation of cellular
processes such as inflammation, and modulation of gut microbiota. In this study we compared …
processes such as inflammation, and modulation of gut microbiota. In this study we compared …
Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin
…, W Ebel, EL Routhier, R Patel, JB Kline, J Zhang… - Cancer immunity, 2007 - AACR
Novel therapeutic agents that are safe and effective are needed for the treatment of
pancreatic, ovarian, lung adenocarcinomas and mesotheliomas. Mesothelin is a glycosyl-…
pancreatic, ovarian, lung adenocarcinomas and mesotheliomas. Mesothelin is a glycosyl-…
Polymer‐based stimuli‐responsive recyclable catalytic systems for organic synthesis
The introduction of stimuli‐responsive polymers into the study of organic catalysis leads to the
generation of a new kind of polymer‐based stimuli‐responsive recyclable catalytic system. …
generation of a new kind of polymer‐based stimuli‐responsive recyclable catalytic system. …
Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients
M Ho, R Hassan, J Zhang, Q Wang, M Onda… - Clinical Cancer …, 2005 - AACR
Purpose: Mesothelin is a glycosyl-phosphatidylinositol–anchored glycoprotein present on
the cell surface. Mesothelin is a differentiation antigen that is highly expressed on …
the cell surface. Mesothelin is a differentiation antigen that is highly expressed on …