[PDF][PDF] Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity

JA Zhang, A Mortazavi, BA Williams, BJ Wold… - Cell, 2012 - cell.com
T cell development comprises a stepwise process of commitment from a multipotent precursor.
To define molecular mechanisms controlling this progression, we probed five stages …

Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer

R Hassan, AT Remaley, ML Sampson, J Zhang… - Clinical cancer …, 2006 - AACR
Purpose: To determine whether mesothelin, a cell surface protein highly expressed in
mesothelioma and ovarian cancer, is shed into serum and if so to accurately measure it. …

[HTML][HTML] A binding domain on mesothelin for CA125/MUC16

O Kaneko, L Gong, J Zhang, JK Hansen… - Journal of biological …, 2009 - ASBMB
Ovarian cancer and malignant mesothelioma frequently express both mesothelin and
CA125 (also known as MUC16) at high levels on the cell surface. The interaction between …

[HTML][HTML] Massively parallel nanowell-based single-cell gene expression profiling

…, A Mir, H Hubschle, J Guillory, W Yuan, J Zhang… - BMC genomics, 2017 - Springer
Background Technological advances have enabled transcriptome characterization of cell
types at the single-cell level providing new biological insights. New methods that enable …

Antibody humanization by framework shuffling

WF Dall'Acqua, MM Damschroder, J Zhang, RM Woods… - Methods, 2005 - Elsevier
We report here the humanization of a mouse monoclonal antibody (mAb B233) using a new
technique which we call framework shuffling. mAb B233 was raised against the human …

Phase 1 study of the antimesothelin immunotoxin SS1P in combination with pemetrexed and cisplatin for front‐line therapy of pleural mesothelioma and correlation of …

R Hassan, E Sharon, A Thomas, J Zhang, A Ling… - Cancer, 2014 - Wiley Online Library
BACKGROUND The primary objective of this study was to determine the safety and
maximum tolerated dose (MTD) of the antimesothelin immunotoxin SS1(dsFv)PE38 (SS1P) (a …

[HTML][HTML] Dietary flavonoids from modified apple reduce inflammation markers and modulate gut microbiota in mice

…, WA Laing, S Martell, H Smith, TK McGhie, J Zhang… - The Journal of …, 2014 - Elsevier
Apples are rich in polyphenols, which provide antioxidant properties, mediation of cellular
processes such as inflammation, and modulation of gut microbiota. In this study we compared …

Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin

…, W Ebel, EL Routhier, R Patel, JB Kline, J Zhang… - Cancer immunity, 2007 - AACR
Novel therapeutic agents that are safe and effective are needed for the treatment of
pancreatic, ovarian, lung adenocarcinomas and mesotheliomas. Mesothelin is a glycosyl-…

Polymer‐based stimuli‐responsive recyclable catalytic systems for organic synthesis

J Zhang, M Zhang, K Tang, F Verpoort, T Sun - Small, 2014 - Wiley Online Library
The introduction of stimuli‐responsive polymers into the study of organic catalysis leads to the
generation of a new kind of polymer‐based stimuli‐responsive recyclable catalytic system. …

Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients

M Ho, R Hassan, J Zhang, Q Wang, M Onda… - Clinical Cancer …, 2005 - AACR
Purpose: Mesothelin is a glycosyl-phosphatidylinositol–anchored glycoprotein present on
the cell surface. Mesothelin is a differentiation antigen that is highly expressed on …