User profiles for Jinchong Xu
 | Jin-chong XuJohns Hopkins University School of Medicine Verified email at jhmi.edu Cited by 2115 |
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3
INTRODUCTION Parkinson’s disease (PD) is the second most common neurodegenerative
disorder and leads to slowness of movement, tremor, rigidity, and, in the later stages of PD, …
disorder and leads to slowness of movement, tremor, rigidity, and, in the later stages of PD, …
Toward the human cellular microRNAome
MicroRNAs are short RNAs that serve as regulators of gene expression and are essential
components of normal development as well as modulators of disease. MicroRNAs generally …
components of normal development as well as modulators of disease. MicroRNAs generally …
Adult conditional knockout of PGC-1α leads to loss of dopamine neurons
Parkinson’s disease (PD) is a chronic progressive neurodegenerative disorder. Recent studies
have implicated a role for peroxisome proliferator-activated receptor γ coactivator protein-…
have implicated a role for peroxisome proliferator-activated receptor γ coactivator protein-…
[HTML][HTML] Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and
sporadic Parkinson's disease (PD). Elevated LRRK2 kinase activity and neurodegeneration are …
sporadic Parkinson's disease (PD). Elevated LRRK2 kinase activity and neurodegeneration are …
Neural cell adhesion molecule L1-transfected embryonic stem cells promote functional recovery after excitotoxic lesion of the mouse striatum
We have generated a murine embryonic stem cell line constitutively expressing L1 at all
stages of neural differentiation to investigate the effects of L1 overexpression on stem cell …
stages of neural differentiation to investigate the effects of L1 overexpression on stem cell …
[PDF][PDF] Defects in mRNA translation in LRRK2-mutant hiPSC-derived dopaminergic neurons lead to dysregulated calcium homeostasis
The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause of familial
Parkinson's disease (PD). This mutation results in dopaminergic neurodegeneration via …
Parkinson's disease (PD). This mutation results in dopaminergic neurodegeneration via …
Proneural transcription factor Atoh1 drives highly efficient differentiation of human pluripotent stem cells into dopaminergic neurons
Human pluripotent stem cells (PSCs) are a promising cell resource for various applications
in regenerative medicine. Highly efficient approaches that differentiate human PSCs into …
in regenerative medicine. Highly efficient approaches that differentiate human PSCs into …
Neural cell adhesion molecule modulates dopaminergic signaling and behavior by regulating dopamine D2 receptor internalization
The dopaminergic system plays an important role in the etiology of schizophrenia, and most
antipsychotic drugs exert their functions by blocking dopamine D 2 receptors (D 2 Rs). Since …
antipsychotic drugs exert their functions by blocking dopamine D 2 receptors (D 2 Rs). Since …
Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity
Translating neuroprotective treatments from discovery in cell and animal models to the clinic
has proven challenging. To reduce the gap between basic studies of neurotoxicity and …
has proven challenging. To reduce the gap between basic studies of neurotoxicity and …
[PDF][PDF] Botch is a γ-glutamyl cyclotransferase that deglycinates and antagonizes Notch
Botch promotes embryonic neurogenesis by inhibiting the initial S1 furin-like cleavage step
of Notch maturation. The biochemical process by which Botch inhibits Notch maturation is not …
of Notch maturation. The biochemical process by which Botch inhibits Notch maturation is not …