Objective Temporal lobe epilepsy (TLE) is a progressive disorder mediated by pathological
changes in molecular cascades and hippocampal neural circuit remodeling that results in …

Synaptic inhibition in the adult brain is primarily mediated by the γ-aminobutyric acid (GABA)
type A receptor (GABA A R). The distribution, properties, and dynamics of these receptors …

Brain-derived neurotrophic factor (BDNF) levels are elevated after status epilepticus (SE),
leading to activation of multiple signaling pathways, including the janus kinase/signal …

Epilepsy is characterized by recurrent, spontaneous seizures and is a major contributor to the
global burden of neurological disease. Although epilepsy can result from a variety of brain …

In this study, we analyzed the impact that spontaneous seizures might have on the plasma
membrane expression, composition and function of GABA A receptors (GABA A Rs). For this, …

Objective Temporal lobe epilepsy ( TLE ) is frequently medically intractable and often progressive.
Compromised inhibitory neurotransmission due to altered γ‐aminobutyric acid ( GABA…

In this study, we used the pilocarpine model of epilepsy to evaluate the involvement of calpain
dysregulation on epileptogenesis. Detection of spectrin breakdown products (SBDPs, a …

When an exhaustive search is impractical in non-clinical environs, people tend to use heuristic
methods to expedite their search. Conversely, clinicians trust exhaustive searches rather …

Nonketotic hyperglycinemia due to deficient glycine cleavage enzyme activity causes a severe
neonatal epileptic encephalopathy. Current therapies based on mitigating glycine excess …

In the continuing goal to merge the fields of computational neuroscience with medical based
neurodiagnostic clinical research this paper presents advancements on machine learning …